Drug-Drug

• Concurrent or previous (within 72 hr) use of acetaminophen may ↓ elimination and ↑ toxicity.
• Concurrent use with high-dose cyclophosphamide in patients with thalassemia may result in cardiac tamponade.
• Concurrent use with itraconazole or phenytoin ↓ blood level effectiveness.
• Long-term continuous therapy with thioguanine may ↑ risk of hepatic toxicity.
• ↑ bone marrow suppression with other antineoplastics or radiation therapy.
• May ↓ the antibody response to and ↑risk of adverse reactions from live-virus vaccines.