Contraindicated in:

• Hypersensitivity;

• Some products contain tartrazine and should be avoided in patients with known intolerance;

• Cross-sensitivity with other benzodiazepines may occur;

• Comatose patients or those with pre-existing CNS depression;

• Uncontrolled severe pain;

• Pulmonary disease;

• Angle-closure glaucoma;

• Porphyria;

• OB: Lactation: May cause CNS depression, flaccidity, feeding difficulties, and weight loss in infants;

• Pedi: Children ≤6 yr.

• Hepatic dysfunction;

• Severe renal impairment;

• History of suicide attempt or substance abuse;

• Geri: Long-acting benzodiazepines cause prolonged sedation in the elderly. Appears on Beers list and is associated with increased risk of falls (↓ dose required or consider short-acting benzodiazepine);

• Debilitated patients (initial dose ↓ required).