Bone marrow depression;
Severe CNS depression/coma;
Lactation: Discontinue drug or bottle-feed.Use Cautiously in:
Long QT syndrome;
Risk factors for QT interval prolongation or ventricular arrhythmias (i.e recent myocardial infarction, heart failure, arrhythmias);
Concurrent use of CYP1A2, CYP2D6, or CYP3A4 inhibitors or QT-interval prolonging drugs;
Hypokalemia or hypomagenesemia;
Malnourished patients or patients with cardiovascular, hepatic, or renal disease (use lower initial dose, titrate more slowly);
Risk factors for stroke (↑ risk of stroke in patients with dementia);
OB: Neonates at ↑ risk for extrapyramidal symptoms and withdrawal after delivery when exposed during the 3rd trimester; use only if benefit outweighs risk to fetus;
Pedi: Children <16 yr (safety not established);
Geri: ↑ risk of mortality in elderly patients treated for dementia-related psychosis.
cloZAPine has been found in Davis's Drug Guide
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