Pharmacokinetics
Absorption: Absorption is generally poor (1–6%) after oral administration.
Distribution: Half of the absorbed dose is bound to hydroxyapatite crystals in areas of increased osteogenesis.
Metabolism and Excretion: Unabsorbed drug is eliminated in the feces; 50% of the absorbed dose is excreted unchanged by the kidneys.
Half-life: 5–7 hr.
TIME/ACTION PROFILE
| ROUTE | ONSET | PEAK | DURATION |
|---|
| PO (Paget's disease) | 1 mo† | unknown | 1 yr |
| PO (heterotopic calcification) | unknown | unknown | several months |
†As measured by decreased urinary hydroxyproline
etidronate has been found in Davis's Drug Guide
If you are a registered user, please login below.
If not, learn more about gaining full access.
- Login
- Try and Buy
- Nursing Central puts five fully integrated references at your fingertips on mobile devices and the web. See how Nursing Central works by clicking the sample entries below or purchase a subscription for the web and your mobile device.
View these free topics online now.
![[Display All Sections]](images/m/display_all_btn.gif)
![[Top]](images/m/top.gif)
CrossLinks
