Pharmacokinetics
Absorption: Rapidly absorbed following oral administration; well absorbed from IM sites.
Distribution: Widely distributed. Crosses the placenta; enters breast milk in minimal concentrations.
Metabolism and Excretion: Mostly metabolized by the GI mucosa and liver by N-acetyltransferase
(rate of acetylation is genetically determined [slow acetylators have ↑ hydralazine levels and ↑ risk of toxicity; fast acetylators have ↓ hydralazine levels and ↓ response]).
Half-life: 2–8 hr.
TIME/ACTION PROFILE (antihypertensive effect)
| ROUTE | ONSET | PEAK | DURATION |
| PO | 45 min | 2 hr | 2–4 hr |
| IM | 10–30 min | 1 hr | 3–8 hr |
| IV | 5–20 min | 15–30 min | 2–6 hr |
hydrALAZINE has been found in Davis's Drug Guide
If you are a registered user, please login below.
If not, learn more about gaining full access.
- Login
- Try and Buy
- Nursing Central puts five fully integrated references at your fingertips on mobile devices and the web. See how Nursing Central works by clicking the sample entries below or purchase a subscription for the web and your mobile device.
View these free topics online now.
![[Display All Sections]](images/m/display_all_btn.gif)
![[Top]](images/m/top.gif)
CrossLinks