Absorption: Rapidly absorbed following oral administration; well absorbed from IM sites.
Distribution: Widely distributed. Crosses the placenta; enters breast milk in minimal concentrations.
Metabolism and Excretion: Mostly metabolized by the GI mucosa and liver by N-acetyltransferase (rate of acetylation is genetically determined [slow acetylators have ↑ hydralazine levels and ↑ risk of toxicity; fast acetylators have ↓ hydralazine levels and ↓ response]).
Half-life: 28 hr.
TIME/ACTION PROFILE (antihypertensive effect)
|PO||45 min ||2 hr||24 hr|
|IM||1030 min||1 hr||38 hr |
|IV||520 min||1530 min||26 hr|
hydrALAZINE has been found in Davis's Drug Guide
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