Contraindicated in:

• Hypersensitivity;

• Possible GI obstruction or hemorrhage;

• History of seizure disorders;

• Pheochromocytoma;

• Parkinson's disease.

• History of depression;

• Diabetes (may alter response to insulin);

• Renal impairment (↓ dose in CCr <50 mL/min);

• Chronic use > 3 mo (↑ risk for tardive dyskinesia);

• OB: Lactation: Safety not established;

• Pedi: Prolonged clearance in neonates can result in high serum concentrations and ↑ the risk for methemoglobinemia. Side effects are more common in children, especially extrapyramidal reactions;

• Geri: More susceptible to oversedation, extrapyramidal reactions, and tardive dyskinesia.