Contraindicated in:

• Hypersensitivity;

• Cross-sensitivity may occur with other NSAIDs, including aspirin;

• Active GI bleeding;

• Ulcer disease;

• Lactation: Passes into breast milk and should not be used by nursing mothers.

• Severe cardiovascular, renal, or hepatic disease;

• History of ulcer disease or any other history of gastrointestinal bleeding (may ↑ risk of GI bleeding);

• Underlying cardiovascular disease (may ↑ risk of MI or stroke);

• Chronic alcohol use/abuse;

• OB: Avoid using during third trimester; may cause premature closure of the ductus arteriosus;

• Pedi: Children <2 yr (safety not established) ;

• Geri: ↑ risk of adverse reactions.