Hypertension Associated with Pheochromocytoma–Before/During Surgery

IV: (Adults) 5 mg given 1–2 hr preop, repeated as necessary. May be infused at a rate of 0.5–1 mg/min during surgery.

IV: IM: Children 1 mg or 0.1 mg/kg (3 mg/m²) given 1–2 hr preop, repeated IV as necessary during surgery.

Prevention of Dermal Necrosis during Infusion of Norepinephrine, Phenylephrine, or Dopamine

IV: (Adults) Add 10 mg phentolamine to every 1000 mL of fluid containing norepinephrine.

Treatment of Dermal Necrosis Following Extravasation of Norepinephrine, Phenylephrine, or Dopamine

Infiltrate: (Adults) 5–10 mg.

Infiltrate: Children 0.1–0.2 mg/kg (up to 10 mg).

Reversal of Intraoral Submucosal Anesthesia Following Dental Procedures (Oraverse)

Infiltrate or Block Injection: (Adults and Children ≥6 yr and >30 kg): Dose administered is based on number of cartridges of local anesthetic with vasoconstrictor administered: 1/2 cartridge local anesthetic–0.2 mg phentolamine ( 1/2 cartridge); 1 cartridge local anesthetic–0.4 mg phentolamine (1 cartridge); 2 cartridges local anesthetic–0.8 mg phentolamine (2 cartridges).

Infiltrate or Block Injection: (Children ≥6 yr and 15–30 kg): Do not exceed dose of 0.2 mg ( 1/2 cartridge).