Hypertension Associated with Pheochromocytoma–Before/During Surgery
IV: (Adults) 5 mg given 1–2 hr preop, repeated as necessary. May be infused at a rate of 0.5–1 mg/min during surgery.
IV: IM: Children 1 mg or 0.1 mg/kg (3 mg/m2) given 1–2 hr preop, repeated IV as necessary during surgery.
Prevention of Dermal Necrosis during Infusion of Norepinephrine, Phenylephrine, or Dopamine
IV: (Adults) Add 10 mg phentolamine to every 1000 mL of fluid containing norepinephrine.
Treatment of Dermal Necrosis Following Extravasation of Norepinephrine, Phenylephrine, or Dopamine
Infiltrate: (Adults) 5–10 mg.
Infiltrate: Children 0.1–0.2 mg/kg (up to 10 mg).
Reversal of Intraoral Submucosal Anesthesia Following Dental Procedures (Oraverse)
Infiltrate or Block Injection: (Adults and Children ≥6 yr and >30 kg): Dose administered is based on number of cartridges of local anesthetic with vasoconstrictor administered: 1/2 cartridge local anesthetic–0.2 mg phentolamine ( 1/2 cartridge); 1 cartridge local anesthetic–0.4 mg phentolamine (1 cartridge); 2 cartridges local anesthetic–0.8 mg phentolamine (2 cartridges).
Infiltrate or Block Injection: (Children ≥6 yr and 15–30 kg): Do not exceed dose of 0.2 mg ( 1/2 cartridge).
phentolamine has been found in Davis's Drug Guide
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