PO (Adults): Secondary amenorrhea400 mg once daily in the evening for 10 days; prevention of postmenopausal estrogen-induced endometrial hyperplasia200 mg once daily at bedtime for 14 days on days 821 of a 28-day cycle or on days 1225 of a 30-day cycle; if patient currently receives ≥1.25 mg/day of estrogen, then a daily of dose of 300 mg of progesterone as 100 mg 2 hr after breakfast and 200 mg at bedtime is used; further adjustments may be required..
Vag (Adults): Secondary amenorrhea45 mg (1 applicatorful of 4% gel) once every other day for up to 6 doses, may be ↑ to 90 mg (1 applicatorful of 8% gel) once every other day for up to 6 doses; Corpus luteum insufficiency or assisted reproduction technologyFor luteal phase support: 90 mg (1 applicatorful of 8% gel) once daily; for in vitro fertilization: 90 mg (1 applicatorful of 8% gel) once daily beginning within 24 hr of embryo transfer and continued through day 30 post-transfer (if pregnancy occurs, treatment may be continued for up to 1012 wk); partial or complete ovarian failure90 mg (1 applicatorful of 8% gel) twice daily while undergoing donor oocyte transfer (if pregnancy occurs, treatment may be continued for up to 1012 wk) Support of embryo implantation and early pregnancy100 mg insert 2 or 3 times daily for up to 10 wk..
IM (Adults): Secondary amenorrhea100150 mg (single dose) or 510 mg daily for 68 days given 810 days before expected menstrual period. Dysfunctional uterine bleeding510 mg daily for 6 days. Corpus luteum insufficiency12.5 mg/day at onset of ovulation for 2 wk; may continue until 11th wk of gestation (unlabeled)..