• PO (Adults): Secondary amenorrhea—400 mg once daily in the evening for 10 days; prevention of postmenopausal estrogen-induced endometrial hyperplasia—200 mg once daily at bedtime for 14 days on days 8–21 of a 28-day cycle or on days 12–25 of a 30-day cycle; if patient currently receives ≥1.25 mg/day of estrogen, then a daily of dose of 300 mg of progesterone as 100 mg 2 hr after breakfast and 200 mg at bedtime is used; further adjustments may be required..

• Vag (Adults): Secondary amenorrhea—45 mg (1 applicatorful of 4% gel) once every other day for up to 6 doses, may be ↑ to 90 mg (1 applicatorful of 8% gel) once every other day for up to 6 doses; Corpus luteum insufficiency or assisted reproduction technology—For luteal phase support: 90 mg (1 applicatorful of 8% gel) once daily; for in vitro fertilization: 90 mg (1 applicatorful of 8% gel) once daily beginning within 24 hr of embryo transfer and continued through day 30 post-transfer (if pregnancy occurs, treatment may be continued for up to 10–12 wk); partial or complete ovarian failure—90 mg (1 applicatorful of 8% gel) twice daily while undergoing donor oocyte transfer (if pregnancy occurs, treatment may be continued for up to 10–12 wk) Support of embryo implantation and early pregnancy—100 mg insert 2 or 3 times daily for up to 10 wk..

• IM (Adults): Secondary amenorrhea—100–150 mg (single dose) or 5–10 mg daily for 6–8 days given 8–10 days before expected menstrual period. Dysfunctional uterine bleeding—5–10 mg daily for 6 days. Corpus luteum insufficiency—12.5 mg/day at onset of ovulation for 2 wk; may continue until 11th wk of gestation (unlabeled)..