Contraindicated in:
None known.

Use Cautiously in:

• Pre-existing pulmonary conditions;

• Hypersensitivity to trastuzumab, Chinese hamster ovary cell proteins, or other components of the product;

• Hypersensitivity to benzyl alcohol (use sterile water for injection instead of bacteriostatic water, which accompanies the vial);

• Geri: May have ↑ risk of cardiac dysfunction;

• OB: Lactation: Use during pregnancy only if clearly needed (can cause fetal harm); not recommended for use during lactation;

• Pedi: Safety not established.

Exercise Extreme Caution in:
Patients with pre-existing cardiac dysfunction.