Interferes with bacterial folic acid synthesis.

Therapeutic Effect(s):
Bactericidal action against susceptible organisms.

Spectrum:

• Some gram-positive pathogens, including:

» Streptococcus pneumoniae ,

» Group A beta-hemolytic streptococci,

» Some staphylococci and Enterococcus .

• Gram-negative spectrum includes the following Enterobacteriaceae:

» Acinetobacter ,

» Citrobacter ,

» Enterobacter ,

» Escherichia coli ,

» Haemophilus influenzae ,

» Klebsiella pneumoniae ,

» Proteus mirabilis ,

» Salmonella ,

» Shigella .

• Other strains of Proteus , some Providencia , some Serratia , and P. jirovecii are also susceptible.