Contraindicated in:

• Hypersensitivity;

• Megaloblastic anemia secondary to folate deficiency.

• Renal impairment (dose ↓ required if CCr ≤30 mL/min);

• Debilitated patients;

• Severe hepatic impairment;

• Folate deficiency;

• OB: Lactation: Pedi: Pregnancy, lactation, or children <12 yr (safety as a single agent not established).