Absorption: Well absorbed from the GI tract.
Distribution: Widely distributed. Crosses the blood-brain barrier and placenta and enters breast milk.
Protein Binding: TMP: 45%; SMX: 68%.
Metabolism and Excretion: Some metabolism by the liver (20%); remainder excreted unchanged by the kidneys.
Half-life: Trimethoprim611 hr; sulfamethoxazole912 hr, both prolonged in renal failure.
TIME/ACTION PROFILE (blood levels)
|PO||rapid||24 hr||612 hr|
|IV||rapid||end of infusion||612 hr|
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