- Hypersensitivity to sulfonamides or trimethoprim;
- History of drug-induced immune thrombocytopenia due to sulfonamides or trimethoprim
- Megaloblastic anemia secondary to folate deficiency;
- Severe hepatic or renal impairment;
- OB: Lactation: Pedi: Pregnancy, lactation, or children <2 mo (can cause kernicterus in neonates). Exception: neonates born to HIV-infected mothers (prophylaxis should be initiated at 4–6 weeks of age).
Use Cautiously in:
- Mild to moderate hepatic or renal impairment (dose ↓ required if CCr <30 mL/min);
- Glucose–6–phosphate dehydrogenase deficiency (↑ risk hemolysis)
- HIV-positive patients (↑ incidence of adverse reactions).
trimethoprim/sulfamethoxazole has been found in Davis's Drug Guide
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