Hypersensitivity to sulfonamides or trimethoprim;
Megaloblastic anemia secondary to folate deficiency;
Severe renal impairment;
OB: Lactation: Pedi: Pregnancy, lactation, or children <2 mo (can cause kernicterus in neonates). Exception: neonates born to HIV-infected mothers (prophylaxis should be initiated at 46 weeks of age).Use Cautiously in:
Impaired hepatic or renal function (dose ↓ required if CCr <30 mL/min);
HIV-positive patients (↑ incidence of adverse reactions).
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