(TMP = trimethoprim; SMX = sulfamethoxazole).
Dosing based on TMP content.
PO: IV: (Adults and Children >2 mo): Mild-moderate infections–6–12 mg TMP/kg/day divided q 12 hr; Serious infection/Pneumocystis–15–20 mg TMP/kg /day/divided q 6–8 hr.
PO: (Adults) Urinary tract infection/chronic bronchitis–1 double strength tablet (160 mg TMP/800 mg SMX) q 12 hr for 10–14 days.
Urinary Tract Infection Prophylaxis
PO: IV: (Adults and Children >2 mo): 2 mg TMP/kg/dose daily or 5 mg TMP/kg/dose twice weekly.
P. jirovecii Pneumonia (Prevention)
PO: (Adults) 1 double strength tablet (160 mg TMP/800 mg SMX) daily (may also be given 3 times weekly).
PO: (Children >1 mo): 150 mg TMP/m2/day divided q 12 hr or given as a single dose on 3 consecutive days/wk (not to exceed 320 mg TMP/1600 mg SMX per day).
trimethoprim/sulfamethoxazole has been found in Davis's Drug Guide
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