CCr <45 mL/min;
OB: Lactation: Pregnancy, lactation.Use Cautiously in:
Concurrent use of NSAIDs in patients with CCr 4579 mL/min (avoid those with short half-lives);
Third space fluid accumulation (ascites, pleural effusions); consider drainage prior to therapy;
Hepatic impairment (dose alteration recommended);
Pedi: Safety not established.
PEMEtrexed has been found in Davis's Drug Guide
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