Should be administered under the supervision of a physician experienced in the use of antineoplastic therapy.

» Prepare solution in a biologic cabinet. Wear gloves, gown, and mask, while handling medication. Discard equipment in specially designated containers.

• pH:
2.0–6.5.

• Direct IV:
Reconstitute each vial with 3.5 mL of 0.9% NaCl. Solution should be clear and colorless; do not administer solutions that are discolored or contain particulate matter.
Concentration: 1mg/mL. Administer reconstituted solution within 8 hr at room temperature; 3 of the 8 hr may be stored in a syringe.

• Rate:
Administer as a 3–5 second bolus injection twice weekly for 2 wk followed by a 10-day rest period. At least 72 hr should elapse between consecutive doses.
If peripheral neuropathy is Grade 1 (paresthesia or loss of reflexes without pain or loss of function) continue prescribed dose. If paresthesia is Grade 1 with pain or Grade 2 (interfering with function but not with daily activities) reduce dose to 1.0 mg/m². If peripheral neuropathy is Grade 2 with pain or Grade 3 (interfering with activities of daily living) withhold dose until toxicity resolves, then re-initiate with a reduced dose of 0.7 mg/m² and decrease frequency to once/wk. If peripheral neuropathy is Grade 4 (permanent sensory loss that interferes with daily function) discontinue bortezomib.