• PO: .

» Administer on an empty stomach 1 hr before or 2 hr after meals, with a full glass of water. Products or foods containing calcium, magnesium, aluminum, iron, or zinc should not be ingested for 4 hr before and 2 hr after administration.

» If gastric irritation occurs, ciprofloxacin may be administered with meals. Food slows and may slightly decrease absorption.

» Regular tablets can be crushed for patients unable to swallow. Extended-release (XR) tablets should be swallowed whole; do not split, crush, or chew.

» Do not administer 5% or 10% oral solution through an enteral feeding tube or with enteral feedings; may decrease absorption.

• pH:
3.3–4.6.

• Intermittent Infusion:
Diluent: Dilute with 0.9% NaCl or D5W. Stable for 14 days at refrigerated or room temperature.
Concentration: 1–2 mg/mL.

• Rate: Administer over 60 min into a large vein to minimize venous irritation.

• Y-Site Compatibility:

» alemtuzumab

» amifostine

» amiodarone

» anakinra

» anidulafungin

» argatroban

» aztreonam

» bivalirudin

» bleomycin

» calcium gluconate

» carboplatin

» carmustine

» caspofungin

» ceftaroline

» ceftazidime

» cisatracurium

» cisplatin

» cyclophosphamide

» cytarabine

» dactinomycin

» daptomycin

» dexmedetomidine

» digoxin

» diltiazem

» diphenhydramine

» dobutamine

» docetaxel

» dopamine

» doripenem

» doxacurium

» doxorubicin

» doxorubicin liposome

» epirubicin

» eptifibatide

» ertapenem

» etoposide

» etoposide phosphate

» fenoldopam

» fludarabine

» gemcitabine

» gentamicin

» granisetron

» hetastarch

» hydromorphone

» idarubicin

» ifosfamide

» irinotecan

» lidocaine

» linezolid

» lorazepam

» mechlorethamine

» meperidine

» methotrexate

» metoclopramide

» metronidazole

» midazolam

» midodrine

» milrinone

» mitoxantrone

» mycophentolate

» nesiritide

» octreotide

» ondansetron

» oxaliplatin

» oxytocin

» paclitaxel

» palonosetron

» pamidronate

» pancuronium

» potassium acetate

» potassium chloride

» promethazine

» quinupristin-dalfopristin

» ranitidine

» remifentanil

» rocuronium

» sodium acetate

» tacrolimus

» telavancin

» teniposide

» thiotepa

» tigecycline

» tirofiban

» tobramycin

» trastuzumab

» vasopressin

» vecuronium

» verapamil

» vincristine

» vinorelbine

» voriconazole

» zolendronic acid

• Y-Site Incompatibility: Manufacturer recommends temporarily discontinuing other solutions when administering ciprofloxacin.

» acyclovir

» aminocaproic acid

» aminophylline

» amphotericin B lipid complex

» amphotericin B liposome

» ampicillin/sulbactam

» azithromycin

» cefepime

» dexamethasone

» drotrecogin

» fluorouracil

» furosemide

» heparin

» hydrocortisone

» magnesium sulfate

» methylprednisolone

» pantoprazole

» pemetrexed

» phenytoin

» piperacillin/tazobactam

» potassium phosphates

» propofol

» rituxumab

» sodium phosphates

» warfarin