PO: May be administered without regard to meals. Products or foods containing calcium, magnesium, aluminum, iron, or zinc should not be ingested for 4 hr before and 2 hr after administration.

IV Adminstration:

• Intermittent Infusion:

Diluent: Premixed bags are diluted in sodium chloride 0.8% and should not be further diluted. Use transfer set whose piercing pin does not require excessive force; insert with a gentle twisting motion until pin is firmly seated.
Concentration: 1.6 mg/mL.

• Rate:
Administer over 60 min. Avoid rapid or bolus infusion.

• Intermittent Infusion:

Diluent: Premixed bags are diluted in sodium chloride 0.8% and should not be further diluted. Use transfer set whose piercing pin does not require excessive force; insert with a gentle twisting motion until pin is firmly seated.
Concentration: 1.6 mg/mL.

• Rate:
Administer over 60 min. Avoid rapid or bolus infusion.

• Y-Site Compatibility:

» alemtuzumab

» anidulafungin

» argatroban

» bivalirudin

» caspofungin

» ceftaroline

» daptomycin

» doripenem

» ertapenem

» mycophenolate

» nesiritide

» octreotide

» oxytocin

» palonosetron

» pemetrexed

» potassium acetate

» tigecycline

» tirofiban

» vasopressin

» zolendronic acid

• Y-Site Incompatibility:

» amphotericin B lipid complex

» furosemide

» voriconazole