Nursing Central: Creatine Kinase and Isoenzymes

Creatine Kinase and Isoenzymes

General

Synonym/Acronym:
CK and isoenzymes.

Common Use:
To monitor myocardial infarction and some disorders of the musculoskeletal system such as Duchenne’s muscular dystrophy.

Specimen:
Serum (1 mL) collected in a red- or tiger-top tube. Serial specimens are highly recommended. Care must be taken to use the same type of collection container if serial measurements are to be taken.

Normal Findings:
(Method: Enzymatic for CK, electrophoresis for isoenzymes; enzyme immunoassay techniques are in common use for CK-MB)

	Conventional & SI Units
Total CK
Newborn–1 yr	Up to 2 × adult values
Male (children and adults)	50–204 units/L
Female (children and adults)	36–160 units/L
CK Isoenzymes by Electrophoresis
CK-BB	Absent
CK-MB	0–4%
CK-MM	96–100%
CK-MB by Immunoassay	0–3 ng/mL
CK-MB Index	0–2.5
CK = creatine kinase; CK-BB = CK isoenzyme in brain; CK-MB = CK isoenzyme in heart; CK-MM = CK isoenzyme in skeletal muscle.The CK-MB index is the CK-MB (by immunoassay) divided by the total CK and then multiplied by 100. For example, a CK-MB by immunoassay of 25 ng/mL with a total CK of 250 units/L would have a CK-MB index of 10.Elevations in total CK occur after exercise. Values in older adults may decline slightly related to loss of muscle mass.

Creatine Kinase and Isoenzymes has been found in Davis's Lab & Diagnostic Tests

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