Increased In:

• Alcoholic cirrhosis (related to release of calcium from body stores associated with acute instances of malnutrition)
• Cancer of the breast, lung, and pancreas (related to metastasis of calcitonin-producing cells to other organs)
• Carcinoid syndrome (related to calcitonin-producing tumor cells)
• C-cell hyperplasia (related to increased production due to hyperplasia)
• Chronic renal failure (related to increased excretion of calcium and retention of phosphorus resulting in release of calcium from body stores; C cells respond to an increase in serum calcium levels)
• Ectopic secretion (especially neuroendocrine origins)
• Hypercalcemia (any cause) (related to increased production by C cells in response to increased calcium levels)
• Medullary thyroid cancer (related to overproduction by cancerous cells)
• MEN type II (related to calcitonin-producing tumor cells)
• Pancreatitis (related to alcoholism or hypercalcemia)
• Pernicious anemia (related to hypergastrinemia)
• Pheochromocytoma (related to calcitonin-producing tumor cells)
• Pregnancy (late) (related to increased maternal loss of circulating calcium to developing fetus; release of calcium from maternal stores stimulates increased release of calcitonin)
• Pseudohypoparathyroidism (related to release of calcium from body stores initiates feedback response from C cells)
• Thyroiditis (related to calcitonin-producing tumor cells)
• Zollinger-Ellison syndrome (related to hypergastrinemia)

Decreased In:
N/A