Nursing Central: Bilirubin and Bilirubin Fractions

Bilirubin and Bilirubin Fractions

Interfering Factors

Drugs that may increase bilirubin levels by causing cholestasis include anabolic steroids, androgens, butaperazine, chlorothiazide, chlorpromazine, chlorpropamide, cinchophen, dapsone, dienoestrol, erythromycin, estrogens, ethionamide, gold salts, hydrochlorothiazide, icterogenin, imipramine, iproniazid, isocarboxazid, isoniazid, meprobamate, mercaptopurine, meropenem, methandriol, nitrofurans, norethandrolone, nortriptyline, oleandomycin, oral contraceptives, penicillins, phenothiazines, prochlorperazine, progesterone, promazine, promethazine, propoxyphene, protriptyline, sulfonamides, tacrolimus, thiouracil, tolazamide, tolbutamide, thiacetazone, trifluoperazine, and trimeprazine.
Drugs that may increase bilirubin levels by causing hepatocellular damage include acetaminophen (toxic), acetylsalicylic acid, allopurinol, aminothiazole, anabolic steroids, asparaginase, azathioprine, azithromycin, carbamazepine, carbutamide, chloramphenicol, clindamycin, clofibrate, chlorambucil, chloramphenicol, chlordane, chloroform, chlorzoxazone, clonidine, colchicine, coumarin, cyclophosphamide, cyclopropane, cycloserine, cyclosporine, dactinomycin, danazol, desipramine, dexfenfluramine, diazepam, diethylstilbestrol, dinitrophenol, enflurane, ethambutol, ethionamide, ethoxazene, factor IX complex, felbamate, flavaspidic acid, flucytosine, fusidic acid, gentamicin, glycopyrrolate, guanoxan, haloperidol, halothane, hycanthone, hydroxyacetamide, ibuprofen, interferon, interleukin-2, isoniazid, kanamycin, labetalol, levamisole, lincomycin, melphalan, mesoridazine, metahexamide, metaxalone, methotrexate, methoxsalen, methyldopa, nitrofurans, oral contraceptives, oxamniquine, oxyphenisatin, pemoline, penicillin, perphenazine, phenazopyridine, phenelzine, phenindione, pheniprazine, phenothiazines, piroxicam, probenecid, procainamide, pyrazinamide, quinine, sulfonylureas, thiothixene, timolol, tobramycin, tolcapone, tretinoin, trimethadione, urethan, and verapamil.
Drugs that may increase bilirubin levels by causing hemolysis include aminopyrine, amphotericin B, carbamazepine, cephaloridine, cephalothin, chloroquine, dimercaprol, dipyrone, furadaltone, furazolidone, mefenamic acid, melphalan, mephenytoin, methylene blue, nitrofurans, nitrofurazone, pamaquine, penicillins, pentaquine, phenylhydrazine, piperazine, pipobroman, primaquine, procainamide, quinacrine, quinidine, quinine, stibophen, streptomycin, sulfonamides, triethylenemelamine, tyrothricin, and vitamin K.
Drugs that may decrease bilirubin levels include anticonvulsants, barbiturates (newborns), chlorophenothane, cyclosporine, flumecinolone (newborns), and salicylates.
Bilirubin is light sensitive. Therefore, the collection container should be suitably covered to protect the specimen from light between the time of collection and analysis.

Bilirubin and Bilirubin Fractions has been found in Davis's Lab & Diagnostic Tests

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