While familial clustering of SLE is relatively rare, twin studies have shown concordance in 24% to 59% of identical twins and in only 2% to 5% of nonidentical twins, which suggests a significant genetic predisposition. Genes encoding proteins of the complement system appear to have the strongest association with SLE. Polymorphisms in the Toll-like receptor-5 (TLR5) gene are also associated with SLE.
Lupus Erythematosus has been found in Diseases and Disorders
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