DRG Category: 824
Mean LOS: 8.6 days
Description SURGICAL: Lymphoma and Non-Acute Leukemia with Other O.R. Procedure with CC
DRG Category: 841
Mean LOS: 6.7 days
Description MEDICAL: Lymphoma and Non-Acute Leukemia with CC
Malignant lymphoma, also called lymphosarcoma or non-Hodgkin's lymphoma (NHL), is a diffuse group of neoplastic diseases characterized by rampant proliferation of lymphocytes. Lymphomas fall into two main categories: Hodgkin's and non-Hodgkin's lymphomas, based primarily on the presence or absence of the Reed-Sternberg cell; when the cells are absent, the disease is classified as NHL (Table 2).
Comparison of Hodgkin's Disease and Non-Hodgkin's Lymphoma
|CHARACTERISTIC||HODGKIN'S||LOW-GRADE NON-HODGKIN'S||ALL OTHER NON-HODGKIN'S|
|Site(s) of origin nodal distribution||Nodal axial (centripetal)||Extranodal, about 10% centrifugal||Extranodal, about 35% centrifugal|
|Central nervous system involvement||Rare, < 1%||Rare, < 1%||Uncommon, < 10%|
|Hepatic involvement||Uncommon||Common, > 50%||Uncommon, < 10%|
|Bone marrow involvement||Uncommon, < 10%||Common, > 50%||Uncommon|
|Marrow involvement adversely affects prognosis||Yes||No||Yes|
|Curable by chemotherapy||Yes||No||Yes|
Of the more than 60,000 new cases of lymphoma diagnosed each year in the United States, approximately 55,000 of them will be NHL. In the past 30 years, the incidence of NHL has increased by more than 80%, making it one of the largest increases of any cancer. This increase is unexpected and is only partially explained by earlier detection because of improved diagnostic techniques or HIV-associated lymphomas.
Malignant lymphoma, or NHL, is a heterogeneous grouping of several disease types that range from the aggressive, rapidly fatal diffuse histiocytic lymphoma to the indolent nodular varieties. Still, all have a less promising prognosis than Hodgkin's disease. NHL can be divided in two groups based on prognosis: indolent lymphomas and aggressive lymphomas. Indolent lymphomas have a comparatively good prognosis with a survival time of up to 10 years. Most are nodular (or follicular) in nature. People with aggressive lymphoma have a poor overall prognosis, although a number of these patients can be cured with chemotherapy. Complications of NHL include hypercalcemia, increased uric acid levels, meningitis, and anemia. As tumors grow, they may compress the vital organs and cause organ dysfunction; problems from organ compression include complications such as increased intracranial pressure.
Lymphoma, Non-Hodgkin's has been found in Diseases and Disorders
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