Diseases and Disorders
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Rheumatic Fever, Acute

GENETIC CONSIDERATIONS

Increased susceptibility to rheumatic fever is known to occur in families. The human leukocyte antigen type DR7DR53 has been associated with the development of valve lesions in severe RHD patients. A novel B-cell alloantigen marker, 883, was identified as a marker, and while genetic studies have observed an autosomal recessive pattern of inheritance, causative mutations remain to be found.

Rheumatic Fever, Acute has been found in Diseases and Disorders

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