Red Book 28e
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Table 3.51. Antimicrobial Therapy for Infants and Children With Meningitis Caused by Streptococcus Pneumoniae on the Basis of Susceptibility Test Results

Table 3-51

Susceptibility Test ResultsAntimicrobial Managementa
Susceptible to penicillinDiscontinue vancomycin
AND
Begin penicillin (and discontinue cephalosporin)
OR
Continue cefotaxime or ceftriaxone aloneb
Nonsusceptible to penicillin (intermediate or resistant)Discontinue vancomycin
AND
ANDContinue cefotaxime or ceftriaxone
Susceptible to cefotaxime and ceftriaxone
Nonsusceptible to penicillin (intermediate or resistant)Continue vancomycin and high-dose cefotaxime or ceftriaxone
ANDAND
Nonsusceptible to cefotaxime and ceftriaxone (intermediate or resistant)Rifampin may be added in selected circumstances (see text)
AND
Susceptible to rifampin

Table 3.51. Antimicrobial Therapy for Infants and Children With Meningitis Caused by Streptococcus Pneumoniae on the Basis of Susceptibility Test Results has been found in Red Book 28e

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