Infection

Drug

Adult dosage

Pediatric dosage

TRYPANOSOMIASIS continued¹¹⁸

Late disease with CNS involvement

Drug of Choice:

Eflornithine^121*

400 mg/kg/d IV in 4 doses X 14d

400 mg/kg/d IV in 4 doses X 14d

OR

Melarsoprol¹²²

2.2 mg/kg/d IV X 10d

2.2 mg/kg/d IV X 10d

T. b. rhodesiense (East African trypanosomiasis, sleeping sickness)

hemolymphatic stage

Drug of choice:

Suramin^*

100–200 mg (test dose) IV, then 1 g IV on days 1,3,7,14 and 21

20 mg/kg on d 1,3,7,14 and 21

Late disease with CNS involvement

Drug of choice:

Melarsoprol¹²²

2–3.6 mg/kg/d IV x 3d; after 7d 3.6 mg/kg/d X 3d; repeat again after 7d

2–3.6 mg/kg/d X 3d; after 7d 3.6 mg/kg/d X 3d; repeat again after 7d

VISCERAL LARVA MIGRANS¹²³(Toxocariasis)

Drug of choice:

Albendazole⁷,¹²

400 mg PO bid X 5d

400 mg PO bid X 5d

OR

Mebendazole⁷

100–200 mg PO bid X 5d

100–200 mg PO bid X 5d

Whipworm, see TRICHURIASIS

Wuchereria bancrofti, see FILARIASIS