Table 3-33
| Disease Category | Drug(s) and Dosea |
| Early localized diseasea | |
| 8 y of age or older | Doxycycline, 100 mg, orally, twice a day for 14-21 daysb |
| Younger than 8 y of age or unable to tolerate doxycycline | Amoxicillin, 50 mg/kg per day, orally, divided into 3 doses (maximum 1.5 g/day) for 14-21 days |
| OR |
| Cefuroxime, 30 mg/kg per day in 2 divided doses (maximum 1000 mg/day) or 1.0 g/day for 14-21 days |
| Early disseminated and late disease | |
| Multiple erythema migrans | Same oral regimen as for early localized disease, but for 21 days |
| Isolated facial palsy | Same oral regimen as for early localized disease, but for 21-28 daysc,d |
| Arthritis | Same oral regimen as for early localized disease, but for 28 days |
| Persistent or recurrent arthritise | Ceftriaxone sodium, 75-100 mg/kg, IV or IM, once a day (maximum 2 g/day) for 14-28 days |
| OR |
| Penicillin, 300 000 U/kg per day, IV, given in divided doses every 4 h (maximum 20 million U/day) for 14-28 days |
| OR |
| Same oral regimen as for early disease |
| Carditis | Ceftriaxone or penicillin: see persistent or recurrent arthritis |
| Meningitis or encephalitis | Ceftriaxonef or penicillin: see persistent or recurrent arthritis, but for 14-28 days |
IV indicates intravenously; IM, intramuscularly.
Table 3.33. Recommended Treatment of Lyme Disease in Children has been found in Red Book
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