Red Book 28e

Table 3.33. Recommended Treatment of Lyme Disease in Children

Table 3-33

Disease CategoryDrug(s) and Dosea
Early localized diseasea
8 y of age or olderDoxycycline, 100 mg, orally, twice a day for 14-21 daysb
Younger than 8 y of age or unable to tolerate doxycyclineAmoxicillin, 50 mg/kg per day, orally, divided into 3 doses (maximum 1.5 g/day) for 14-21 days
OR
Cefuroxime, 30 mg/kg per day in 2 divided doses (maximum 1000 mg/day) or 1.0 g/day for 14-21 days
Early disseminated and late disease
Multiple erythema migransSame oral regimen as for early localized disease, but for 21 days
Isolated facial palsySame oral regimen as for early localized disease, but for 21-28 daysc,d
ArthritisSame oral regimen as for early localized disease, but for 28 days
Persistent or recurrent arthritiseCeftriaxone sodium, 75-100 mg/kg, IV or IM, once a day (maximum 2 g/day) for 14-28 days
OR
Penicillin, 300 000 U/kg per day, IV, given in divided doses every 4 h (maximum 20 million U/day) for 14-28 days
OR
Same oral regimen as for early disease
CarditisCeftriaxone or penicillin: see persistent or recurrent arthritis
Meningitis or encephalitisCeftriaxonef or penicillin: see persistent or recurrent arthritis, but for 14-28 days


IV indicates intravenously; IM, intramuscularly.

Table 3.33. Recommended Treatment of Lyme Disease in Children has been found in Red Book 28e

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