Primary mood disorder characterized by a sustained feeling of sadness and/or decreased interest in all or most activities once enjoyed, which represents a change from previous state
The 12-month and lifetime prevalence of major depressive disorder (MDD): 10.4% and 20.6%, respectively (1); predominant age: low risk before early teens; highest prevalence in teens and young adults
Etiology and Pathophysiology
Diverse theories regarding the pathophysiology
Twin studies suggest 37% concordance.
- Female > male (2:1)
- Adverse life events (2)
- First-degree relative with depression, bipolar, suicide, substance abuse; spouse with depression
- Presence of comorbid medical conditions including neurodegenerative diseases
Commonly Associated Conditions
Bipolar disorder, cyclothymic disorder, grief reaction, anxiety disorders, somatoform disorders, schizophrenia/schizoaffective disorders, conduct disorder, substance abuse
There's more to see -- the rest of this topic is available only to subscribers.