Disseminated Intravascular Coagulation
- Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by diffuse activation of intravascular coagulation. It can originate from and cause damage to the microvasculature, which, if sufficiently severe, can produce organ dysfunction.
- Excessive activation of coagulation cascade can cause microvascular thrombi from the deposition of fibrin. However, ongoing consumption of coagulation proteins and platelets may also cause severe bleeding.
- Acute DIC occurs when rapid consumption of coagulation factors and platelets cannot be adequately compensated. It is caused by sudden exposure of blood to one or more procoagulants, such as tissue factor (TF) or lipopolysaccharides. It has a high tendency to cause bleeding, often requiring urgent or emergent treatment.
- Chronic DIC is typically seen in patients with smaller amounts of thrombin for prolonged periods such as in advanced malignancy, vasculitis, aneurysms, or with large healing hematomas. It presents more frequently with thrombosis.
- Synonym(s): consumptive coagulopathy or defibrination syndrome
- It could be as common as 1% in hospitalized patients.
- 18.1% in ICU patients with severe sepsis (using International Society on Thrombosis and Haemostasis [ISTH] criteria) (1)
- 16.9% in ED or ICU patients with severe trauma (ISTH criteria)
- Incidence of DIC increases with age.
- Predominant sex: male > female
- Systemic formation of fibrin is the result of the simultaneous coexistence of the following (2):
- TF expressed by cancer cells, endothelial cells, and mononuclear cells complexes with factor VIIa and activates thrombin formation. Thrombin then cleaves fibrinogen to form fibrin, activates factors for further thrombin formation, and enhances platelet aggregation.
- Suppression of the physiologic anticoagulant pathways
- Antithrombin is depleted by consumption, degradation, and impaired synthesis.
- Low proteins C and S due to decreased synthesis and decreased levels of thrombomodulin (TM)
- Impaired fibrinolysis
- Thrombin causes release of plasminogen activator inhibitor type 1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI), both of which impair plasminogen activation.
- Activation of inflammatory pathways increasing platelet adhesion
- Increasing evidence suggests that damage-associated pattern (i.e., extracellular histones) and the formation of neutrophil extracellular traps (NETs) play an important role in DIC pathophysiology (3):
- Histones are released from endothelial cells following damage or an exaggerated inflammatory response.
- Uncontrolled NETs formation by neutrophils occurs in the setting of sepsis, micro- or macro-vascular thrombosis, and multiple organ injury.
- Together, they simultaneously affect coagulation, fibrinolysis, and inflammation in a reciprocal fashion:
- Triggering procoagulant effect by TF expression, platelet activation, and reducing endogenous anticoagulants
- Producing antifibrinolytic effect by attenuating plasminogen activation, enhancing clot resistance to plasmin, and increasing clot density and fibre diameter
- Propagating coagulation by pro-inflammatory cytokine release and direct cytotoxic effects
Etiology and Pathophysiology
- Causes can be classified as acute or chronic, systemic or localized.
- Sepsis/severe infection (any microorganism)
- Leukemias, especially acute promyelocytic leukemia
- Mucin-producing solid tumors: pancreatic cancer, gastric, breast, ovarian, etc.
- Brain tumors
- Trauma (polytrauma, neurotrauma, fat embolism)
- Obstetric calamities (amniotic fluid embolism; abruptio placentae; hemorrhage; acute fatty liver of pregnancy; fetal demise; hemolysis, elevated liver function, and low platelets [HELLP] syndrome; preeclampsia)
- Vascular disorders, such as Kasabach-Merritt syndrome, large vascular aneurysms, and thrombosis
- Organ destruction (severe pancreatitis, severe liver failure)
- Severe toxic or immunologic reactions
- Snake bite
- Recreational drugs
- Transfusion reactions
- Transplant rejection
- Thermal injury
- Infant and adult respiratory distress syndrome
- Purpura fulminans from congenital protein C deficiency, protein S deficiency, or acquired protein C deficiency from meningococcal infection
See “Etiology and Pathophysiology.”
Aggressive interventions aimed at early treatment of the underlying clinical conditions
Commonly Associated Conditions
Thromboembolic phenomena are associated with venous thrombosis, thrombotic vegetations on the aortic heart valve, arterial emboli, and neonatal purpura fulminans (homozygous protein C or protein S deficiency).
- Neonatal purpura fulminans is associated with DIC and protein C or protein S deficiency (homozygous).
- Patient with large hemangiomas can develop Kasabach-Merritt syndrome, a localized form of DIC, from consumptive coagulopathy within the hemangioma.
- Any obstetric complications resulting in fetal anoxia/birth asphyxia may cause DIC.
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Domino, Frank J., et al., editors. "Disseminated Intravascular Coagulation." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2020. www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816384/all/Disseminated_Intravascular_Coagulation.
Disseminated Intravascular Coagulation. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2020. https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816384/all/Disseminated_Intravascular_Coagulation. Accessed May 28, 2023.
Disseminated Intravascular Coagulation. (2020). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical Consult (27th ed.). Wolters Kluwer. https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816384/all/Disseminated_Intravascular_Coagulation
Disseminated Intravascular Coagulation [Internet]. In: Domino FJF, Baldor RAR, Golding JJ, Stephens MBM, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2020. [cited 2023 May 28]. Available from: https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816384/all/Disseminated_Intravascular_Coagulation.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Disseminated Intravascular Coagulation ID - 816384 ED - Domino,Frank J, ED - Baldor,Robert A, ED - Golding,Jeremy, ED - Stephens,Mark B, BT - 5-Minute Clinical Consult, Updating UR - https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816384/all/Disseminated_Intravascular_Coagulation PB - Wolters Kluwer ET - 27 DB - 5-Minute Clinical Consult DP - Unbound Medicine ER -