Disseminated Superficial Actinic Porokeratosis (DSAP)

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Basics

Description

  • A disorder of keratinization
  • Lesions of the skin with conical papules of a red and brown color surrounding the hair follicle
  • Edges may become raised over time (1).
  • Typically found in 30 to 40 year olds (2)
  • Commonly located on the arms and legs

Etiology and Pathophysiology

Proliferation of atypical keratinocytes from a mutant clonal cell line

Genetics
  • Genetic studies have revealed mutation of MVK (3).
  • Mutation of keratinocyte proliferation and differentiation (3)
  • Autosomal dominant with variable penetrance (1)

Risk Factors

  • UV-light exposure (2)
  • Male sex (1)
  • Immune suppression (1)
  • Infection (1)

General Prevention

Sunscreen and avoidance of UV exposure (2)

Commonly Associated Conditions

Skin malignancies in up to 10% of people (1)

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Basics

Description

  • A disorder of keratinization
  • Lesions of the skin with conical papules of a red and brown color surrounding the hair follicle
  • Edges may become raised over time (1).
  • Typically found in 30 to 40 year olds (2)
  • Commonly located on the arms and legs

Etiology and Pathophysiology

Proliferation of atypical keratinocytes from a mutant clonal cell line

Genetics
  • Genetic studies have revealed mutation of MVK (3).
  • Mutation of keratinocyte proliferation and differentiation (3)
  • Autosomal dominant with variable penetrance (1)

Risk Factors

  • UV-light exposure (2)
  • Male sex (1)
  • Immune suppression (1)
  • Infection (1)

General Prevention

Sunscreen and avoidance of UV exposure (2)

Commonly Associated Conditions

Skin malignancies in up to 10% of people (1)

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