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Acute adrenal insufficiency

Etiology

Primary adrenal insufficiency (Addison’s disease)

  • Autoimmune
  • Surgical removal or trauma
  • Infection, e.g., tuberculosis, histoplasmosis
  • Adrenal hemorrhage
  • Metastatic cancer
  • Adrenoleukodystrophy
  • Hemochromatosis or amyloidosis
  • Congenital adrenal hyperplasia

Secondary adrenal insufficiency

  • Pituitary failure (atrophy, necrosis, tumor)
  • Exogenous steroids

DDx

  • Other types of shock, e.g., septic, cardiogenic, hypovolemic, anaphylactic
  • Hyperkalemia due to other causes, e.g., renal failure, rhabdomyolysis
  • Hyponatremia due to other causes, e.g., SIADH, cirrhosis, vomiting
  • Abdominal pain due to other causes

See related DDx

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Last updated: January 14, 2015

Citation

Zeiger, Roni F.. "Acute Adrenal Insufficiency." Diagnosaurus, 4th ed., McGraw-Hill Education, 2015. 5minute, www.unboundmedicine.com/5minute/view/Diagnosaurus/114318/all/Acute_adrenal_insufficiency.
Zeiger RF. Acute adrenal insufficiency. Diagnosaurus. 4th ed. McGraw-Hill Education; 2015. https://www.unboundmedicine.com/5minute/view/Diagnosaurus/114318/all/Acute_adrenal_insufficiency. Accessed May 23, 2019.
Zeiger, R. F. (2015). Acute adrenal insufficiency. In Diagnosaurus. Available from https://www.unboundmedicine.com/5minute/view/Diagnosaurus/114318/all/Acute_adrenal_insufficiency
Zeiger RF. Acute Adrenal Insufficiency [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2015. [cited 2019 May 23]. Available from: https://www.unboundmedicine.com/5minute/view/Diagnosaurus/114318/all/Acute_adrenal_insufficiency.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Acute adrenal insufficiency ID - 114318 A1 - Zeiger,Roni F, Y1 - 2015/01/14/ BT - Diagnosaurus UR - https://www.unboundmedicine.com/5minute/view/Diagnosaurus/114318/all/Acute_adrenal_insufficiency PB - McGraw-Hill Education ET - 4 DB - 5minute DP - Unbound Medicine ER -