Select 5-Minute Pediatrics Topics
Leukocytosis
Basics
Description
Leukocytosis refers to a total white blood cell (WBC) count above the normal range for age.
Risk Factors
- Very low-birth-weight neonates
- Immunodeficiencies or immunocompromised states
- Inflammatory disorders
- Autoimmune disorders
ALERT
Children with trisomy 21 (Down syndrome) have an increased risk of developing transient myeloproliferative disorder (TMD) or leukemoid reactions.
Children with trisomy 21 (Down syndrome) have an increased risk of developing transient myeloproliferative disorder (TMD) or leukemoid reactions.
Pathophysiology
Leukocytosis results from increased marrow production, demargination, prolonged cell survival, and/or defective extravasculation in response to external stimuli or, less commonly, from an underlying marrow disorder.
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Citation
Cabana, Michael D., editor. "Leukocytosis." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. 5-Minute Clinical Consult, www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14015/all/Leukocytosis.
Leukocytosis. In: Cabana MDM, ed. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14015/all/Leukocytosis. Accessed June 5, 2023.
Leukocytosis. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics (7th ed.). Wolters Kluwer Health. https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14015/all/Leukocytosis
Leukocytosis [Internet]. In: Cabana MDM, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2023 June 05]. Available from: https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14015/all/Leukocytosis.
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