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Leukocytosis

Leukocytosis is a topic covered in the Select 5-Minute Pediatrics Topics.

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Basics

Description

Leukocytosis refers to a total white blood cell (WBC) count above the normal range for age.

Risk Factors

  • Very low-birth-weight neonates
  • Immunodeficiencies or immunocompromised states
  • Inflammatory disorders
  • Autoimmune disorders
ALERT
Children with trisomy 21 (Down syndrome) have an increased risk of developing transient myeloproliferative disorder (TMD) or leukemoid reactions.

Pathophysiology

Leukocytosis results from increased marrow production, demargination, prolonged cell survival, and/or defective extravasculation in response to external stimuli or, less commonly, from an underlying marrow disorder.

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Citation

Cabana, Michael D., editor. "Leukocytosis." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. 5minute, www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14015/all/Leukocytosis.
Leukocytosis. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14015/all/Leukocytosis. Accessed May 19, 2019.
Leukocytosis. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14015/all/Leukocytosis
Leukocytosis [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 May 19]. Available from: https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14015/all/Leukocytosis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Leukocytosis ID - 14015 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14015/all/Leukocytosis PB - Wolters Kluwer Health ET - 7 DB - 5minute DP - Unbound Medicine ER -