Hypogammaglobulinemia

Hypogammaglobulinemia is a topic covered in the Select 5-Minute Pediatrics Topics.

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Basics

Description

  • A disorder of the humoral immune system characterized by deficient or absent immunoglobulins and the inability to produce specific antibody
  • Subtypes include primary immunodeficiency and secondary deficiency due to other extrinsic disease (i.e., malignancy).

Epidemiology

Incidence and prevalence depends on underlying defect or cause. Antibody deficiency syndromes represent ∼70% of primary immune deficiencies.

Risk Factors

Genetic defects have been identified in many cases, which are identified in the “Differential Diagnosis.”

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