Transient Erythroblastopenia of Childhood

Transient Erythroblastopenia of Childhood is a topic covered in the Select 5-Minute Pediatrics Topics.

To view the entire topic, please or .

5-Minute Clinical Consult (5MCC) app and website powered by Unbound Medicine helps you diagnose and manage 900+ medical conditions. Exclusive bonus features include Diagnosaurus DDx, 200 pediatrics topics, and medical news feeds. Explore these free sample topics:

-- The first section of this topic is shown below --

Basics

Description

An acquired, self-limited suppression of red cell production in an otherwise healthy child

Epidemiology

  • Mean age at diagnosis is 26 months.
  • <10% are >3 years of age at diagnosis.
  • Slight male predominance (male/female 5.1:3.1)
  • No seasonal predominance

Risk Factors

Genetics

  • There is no simple genetic pattern.
  • Familial transient erythroblastopenia of childhood has been reported (rarely), suggesting a combination of environmental factors and genetic propensity.

General Prevention

There is no known way to prevent transient erythroblastopenia of childhood.

Etiology

  • Unknown
  • Possible viral causes include parvovirus B19 and human herpesvirus 6 (HHV-6), but this remains hypothetical.
  • A serum inhibitor, such as an IgG directed at the committed erythroid stem cell progenitor, has also been proposed but not yet proven.

-- To view the remaining sections of this topic, please or --

Basics

Description

An acquired, self-limited suppression of red cell production in an otherwise healthy child

Epidemiology

  • Mean age at diagnosis is 26 months.
  • <10% are >3 years of age at diagnosis.
  • Slight male predominance (male/female 5.1:3.1)
  • No seasonal predominance

Risk Factors

Genetics

  • There is no simple genetic pattern.
  • Familial transient erythroblastopenia of childhood has been reported (rarely), suggesting a combination of environmental factors and genetic propensity.

General Prevention

There is no known way to prevent transient erythroblastopenia of childhood.

Etiology

  • Unknown
  • Possible viral causes include parvovirus B19 and human herpesvirus 6 (HHV-6), but this remains hypothetical.
  • A serum inhibitor, such as an IgG directed at the committed erythroid stem cell progenitor, has also been proposed but not yet proven.

There's more to see -- the rest of this entry is available only to subscribers.