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Malabsorption is a topic covered in the Select 5-Minute Pediatrics Topics.

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  • Malabsorption is characterized as a syndrome, as opposed to a disease entity, and is defined as any state in which there is a disturbance of digestion and/or absorption of nutrients across the intestinal mucosa.
  • The classical symptoms of malabsorption include chronic diarrhea, abdominal distention, and failure to thrive.


Depends on the underlying disease causing malabsorption


The most common causes of malabsorption in developed countries are as follows:

  • Postenteritis syndrome
  • Cow’s milk protein intolerance
  • Giardiasis
  • Celiac disease
  • Cystic fibrosis
  • Inflammatory bowel disease (IBD)


  • Depends on the nutrient affected
    • Carbohydrate
      • Monosaccharide: congenital glucose-galactose deficiency, fructose intolerance
      • Disaccharide: lactase deficiency (congenital or acquired), sucrase-isomaltase deficiency
      • Polysaccharide: amylase deficiency (congenital or acquired)
    • Fat
      • Bile salt deficiency: cholestasis, resection of terminal ileum
      • Exocrine pancreatic insufficiency: cystic fibrosis, chronic pancreatitis
      • Inadequate surface area: celiac disease, flat villous lesions
    • Protein
      • Protein-losing enteropathy: intestinal lymphangiectasia, congenital heart failure
      • Exocrine pancreatic insufficiency: cystic fibrosis, Shwachman-Diamond syndrome
      • Inadequate surface area: celiac disease
  • According to the place where the alteration occurs
    • Mucosal abnormality
      • Anatomic: post-enteritis syndrome, celiac disease, IBD
      • Functional: disaccharidase deficiencies
    • Luminal abnormality
      • Exocrine pancreatic insufficiency: cystic fibrosis, Shwachman-Diamond syndrome
      • Bile salt insufficiency: biliary cholestatic liver disease, ileal resection
    • Anatomic abnormality
      • Short gut: surgical resection
      • Motility disturbance: intestinal pseudo-obstruction

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Cabana, Michael D., editor. "Malabsorption." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. 5minute, www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14208/all/Malabsorption.
Malabsorption. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14208/all/Malabsorption. Accessed June 16, 2019.
Malabsorption. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14208/all/Malabsorption
Malabsorption [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 June 16]. Available from: https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14208/all/Malabsorption.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Malabsorption ID - 14208 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14208/all/Malabsorption PB - Wolters Kluwer Health ET - 7 DB - 5minute DP - Unbound Medicine ER -