Lidocaine
Xylocaine, L-M-X, Lidoderm, Gen7T Plus, many different brands of topical products, and generics
Antiarrhythmic class Ib, local anesthetic
| B | 1 | Yes | Yes | No |
| Key |
- Injection: 0.5%, 1%, 1.5%, 2%, 4% (1% sol ¼ 10 mg/mL)
- IV infusion (in D 5 W): 0.4% (4 mg/mL) (250, 500 mL); 0.8% (8 mg/mL) (250 mL)
- Injection with epinephrine (some preparations may contain metasulfite and parabens or are preservative free):
- Injection with 1:100,000 epinephrine: 1%, 2% lidocaine
- Injection with 1:200,000 epinephrine: 0.5%, 1%, 1.5%, 2% lidocaine
- Ointment: 4% (50 g), 5% (30, 50 g)
- Cream, topical: 3% (30, 85 g), 4% (L-M-X-4 and generics) [OTC] (5, 15, 30, 45 g), 5% (L-M-X-5 and generics) [OTC] (15, 30 g); may contain benzyl alcohol
- Cream, rectal: 5% (L-M-X-5 and others; 15, 30 g); contains benzyl alcohol
- Gel (external): 2% (5, 10, 20, 30 mL), 3% (10, 30 mL), 4% (10, 30 , 113 g), 5% (10, 30, 113 g); may contain benzyl alcohol, EDTA
- Lotion: 3% (118, 177 mL), 4% (88 mL)
- Solution (external): 4% (50 mL); may contain parabens
- Aerosol spray (external): 4% (104 mL)
- Transdermal patch:
- Gen7T Plus and generics: 3.5% (5s, 10s, 15s); may contain menthol
- Lidocaine Pain Relief and generics [OTC]: 4% (5s, 10s); may contain menthol, capsaicin, and methyl salicylate
- Lidoderm and generics: 5% (1s, 15s, 30s)
For explanation of icons, see p. 763 FORMULARY
- Oral solution (mouth/throat): 2% (15, 100 mL), 4% (4 mL)
- Topical cream or gel 2.5% with 2.5% prilocaine: See Lidocaine and Prilocaine.
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Citation
Hughes, Helen K., and Lauren K. Kahl, editors. "Lidocaine." Harriet Lane Handbook, 23rd ed., Elsevier, 2024. Harriet Lane, www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309183/0/Lidocaine.
Lidocaine. In: Hughes HKH, Kahl LKL, eds. Harriet Lane Handbook. Elsevier; 2024. https://www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309183/0/Lidocaine. Accessed November 2, 2026.
Lidocaine. (2024). In Hughes, H. K., & Kahl, L. K. (Eds.), Harriet Lane Handbook (23rd ed.). Elsevier. https://www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309183/0/Lidocaine
Lidocaine [Internet]. In: Hughes HKH, Kahl LKL, eds. Harriet Lane Handbook. Elsevier; 2024. [cited 2026 November 02]. Available from: https://www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309183/0/Lidocaine.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Lidocaine
ID - 309183
ED - Hughes,Helen K,
ED - Kahl,Lauren K,
BT - Harriet Lane Handbook
UR - https://www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309183/0/Lidocaine
PB - Elsevier
ET - 23
DB - Harriet Lane
DP - Unbound Medicine
ER -

Harriet Lane Handbook

