Pralidoxime Chloride + Atropine
Protopam, 2-PAM, and generics
In combination with atropine: Duodote, ATNAA
Antidote, organophosphate poisoning
| C | ? | Yes | Yes | No |
| Key |
- Injection (Protopam): 1000 mg
- In combination with atropine (Duodote, ATNNA):
- Injection for intramuscular injection in autoinjector device: 600 mg/2 mL of pralidoxime and 2.1 mg/0.7 mL of atropine; contains benzyl alcohol. Duodote or ATNNA must be administered by emergency medical services personnel who have had adequate training in the recognition and treatment of nerve agent or insecticide intoxication.
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Citation
Hughes, Helen K., and Lauren K. Kahl, editors. "Pralidoxime Chloride + Atropine." Harriet Lane Handbook, 23rd ed., Elsevier, 2024. Harriet Lane, www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309340/2/Pralidoxime_Chloride +_Atropine.
Pralidoxime Chloride + Atropine. In: Hughes HKH, Kahl LKL, eds. Harriet Lane Handbook. Elsevier; 2024. https://www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309340/2/Pralidoxime_Chloride +_Atropine. Accessed August 24, 2026.
Pralidoxime Chloride + Atropine. (2024). In Hughes, H. K., & Kahl, L. K. (Eds.), Harriet Lane Handbook (23rd ed.). Elsevier. https://www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309340/2/Pralidoxime_Chloride +_Atropine
Pralidoxime Chloride + Atropine [Internet]. In: Hughes HKH, Kahl LKL, eds. Harriet Lane Handbook. Elsevier; 2024. [cited 2026 August 24]. Available from: https://www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309340/2/Pralidoxime_Chloride +_Atropine.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Pralidoxime Chloride + Atropine
ID - 309340
ED - Hughes,Helen K,
ED - Kahl,Lauren K,
BT - Harriet Lane Handbook
UR - https://www.unboundmedicine.com/harrietlane/view/Harriet_Lane_Handbook/309340/2/Pralidoxime_Chloride +_Atropine
PB - Elsevier
ET - 23
DB - Harriet Lane
DP - Unbound Medicine
ER -

Harriet Lane Handbook

