Tazicef and generics; previously available as Fortaz
Antibiotic, cephalosporin (third generation)

B	1	Yes	Yes	No
Key

• Injection: 1, 2, 6 g
• Frozen injection: 1 g/50 mL 4.4% dextrose, 2 g/50 mL 3.2% dextrose (iso-osmotic solutions)
• Contains 2.3 mEq Na/g drug

Dosing

• Neonate (IV/IM):
  • Postnatal age ≤7 days: 50 mg/kg/dose Q12 hr
  • Postnatal age >7–28 days:
    • <1000 g:
      • Postnatal age 8–14 days: 50 mg/kg/dose Q12 hr
      • Postnatal age 15–28 days: 50 mg/kg/dose Q8 hr
    • ≥1000 g: 50 mg/kg/dose Q8 hr
  • Meningitis:
    • Postnatal age ≤7 days: 50 mg/kg/dose Q8–12 hr
    • Postnatal age >7 days: 50 mg/kg/dose Q8 hr
• Infant (>1 mo), child and adolescent (IV/IM):
  • Mild/moderate infection:100–150 mg/kg/24 hr ÷ Q8 hr; max. dose: 6 g/24 hr
  • Meningitis: 150–200 mg/kg/24 hr ÷ Q8 hr ( max. dose: 6 g/24 hr)
  • Serious Pseudomonas infections: 200–300 mg/kg/24 hr ÷ Q8 hr ( max. dose: 12 g/24 hr)
  • Cystic fibrosis: 200–400 mg/kg/24 hr ÷ Q6–8 hr ( max. dose: 12 g/24 hr)
• Adult (IV/IM): 1–2 g/dose Q8–12 hr; max. dose: 6 g/24 hr

Notes

• Use with caution in penicillin-allergic patients or in presence of renal impairment. Good Pseudomonas coverage and CSF penetration. May cause rash, liver enzyme elevations, and false-positive urine-reducing substance (e.g., Clinitest, Benedict's solution, or Fehling's solution) and Coombs test. Enzymatic glucose oxidase urinary glucose tests (e.g., Clinistix or Tes-Tape) are recommended. Probenecid increases serum ceftazidime levels. Adjust dose in renal failure (see Chapter 31 ). Nonconvulsive status epilepticus, neuromuscular excitability, and myoclonia may occur with elevated levels of ceftazidime.