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98 results
  • Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. [Randomized Controlled Trial]
    N Engl J Med. 2020 12 31; 383(27):2603-2615.Polack FP, Thomas SJ, … C4591001 Clinical Trial Group
  • CONCLUSIONS: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older. Safety over a median of 2 months was similar to that of other viral vaccines. (Funded by BioNTech and Pfizer; number, NCT04368728.).
  • [Pericarditis is inflammation of the pericardium, which rheumatologists should know]. [Review]
    Z Rheumatol. 2021 Feb; 80(1):54-64.Krusche M, Schneider U, Ruffer N
  • Pericarditis is the term for inflammatory involvement of the pericardium, which can be associated with pericardial effusion and myocardial involvement (perimyocarditis). Pericarditis can be present in the context of systemic inflammatory rheumatic diseases but can also constitute a distinct disease entity. Idiopathic recurrent pericarditis (IRP) describes relapsing conditions of pericarditis with…
  • [Thiamazole-induced arthritis]. [Case Reports]
    Z Rheumatol. 2021 Mar; 80(2):180-183.Brinkman A, Schneider U, … Krusche M
  • We report the case of a 42-year-old male patient with acute onset of asymmetrical polyarthritis of the medium and large joints as well as fever and elevated serological inflammation markers. The symptoms began shortly after initiation of thiamazole treatment for newly diagnosed Graves' disease. Antithyroid arthritis syndrome (AAS) is a rare but serious adverse side effect of antithyroid treatment…
  • The simian crease: Relationship to various genetic disorders. [Review]
    Clin Anat. 2019 Nov; 32(8):1042-1047.Wahl L, Dupont G, Tubbs RS
  • The creases of the palm have been of interest for clinicians, anthropologists, and palmists for hundreds of years, but the variations in them have only been studied during the past 50 years. The simian crease, aptly named for its resemblance to the palmar creases of nonhuman simian primates, has received recognition clinically and anthropologically owing to its abnormal appearance and confounding…
  • Advances in n-3 polyunsaturated fatty acid nutrition. [Review]
    Asia Pac J Clin Nutr. 2019; 28(1):1-5.Li D, Wahlqvist ML, Sinclair AJ
  • There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). N-3 PUFA also contribute to human health maintenance through correction of arrhythmias, inhibition of platelet aggregation and prolongation of clotting time, lowering blood pressure, lowering serum triglyceride…
  • Alternative treatments for adults with attention-deficit hyperactivity disorder (ADHD). [Review]
    Ann N Y Acad Sci. 2001 Jun; 931:310-41.Arnold LE
  • A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting controlled studies through mere hypotheses to positive controlled double-blind clinical…
  • [Telemedicine in rheumatology]. [Journal Article]
    Z Rheumatol. 2020 Nov; 79(9):883-892.Krusche M, Mühlensiepen F, … Knitza J
  • Due to the outbreak of the COVID-19 pandemic, in recent months we have experienced deep changes in our daily and professional lives. In the context of pandemic containment, routine rheumatological procedures have changed in many areas. To guarantee sufficient protection against the infection for patients and staff, telemedicine (especially telephone and video consultation) has increasingly been u…
  • #Covid4Rheum: an analytical twitter study in the time of the COVID-19 pandemic. [Journal Article]
    Rheumatol Int. 2020 12; 40(12):2031-2037.Ruffer N, Knitza J, Krusche M
  • Social media services, such as Twitter, offer great potential for a better understanding of rheumatic and musculoskeletal disorders (RMDs) and improved care in the field of rheumatology. This study examined the content and stakeholders associated with the Twitter hashtag #Covid4Rheum during the COVID-19 pandemic. The content analysis shows that Twitter connects stakeholders of the rheumatology co…
  • [Auricular chondritis as first symptom of ANCA-associated vasculitis]. [Case Reports]
    Z Rheumatol. 2020 Nov; 79(9):902-905.Pfannkuch L, Schneider U, … Krusche M
  • Auricular chondritis frequently occurs in relapsing polychondritis. In addition to the primary form of the disease up to 30% of cases of chondritis can be secondary, e.g. due to autoimmune diseases. We describe the case of a 62-year-old male patient with auricular chondritis as the first symptom of granulomatosis with polyangiitis. Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis…
  • [Mobile apps and their usage in rheumatology]. [Journal Article]
    Z Rheumatol. 2020 Aug; 79(6):554-561.Krusche M, Ruffer N, … Knitza J
  • The increasing use of smartphones is accompanied by a significant increase in the use of mobile applications (apps). Chronically ill patients could permanently profit from this development.This development is fuelled by the Digital Healthcare Act (DVG), whereby patients have a legal claim to certain apps, so-called digital health applications (DiGAs), which are reimbursed by the statutory health …
  • [Muscular polyarteritis nodosa-a case-based review]. [Case Reports]
    Z Rheumatol. 2019 Mar; 78(2):173-179.Krusche M, Ruffer N, … Kötter I
  • CONCLUSIONS: With respect to own experiences and the reviewed literature, muscular PAN should be considered as a possible diagnosis in cases of myalgia with elevated inflammatory markers but normal CK levels and a lack of further symptoms typical for vasculitis.
  • FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells. [Journal Article]
    Oncol Lett. 2015 Mar; 9(3):1482-1488.Halacli SO, Dogan AL
  • Loss of Forkhead box P1 (FOXP1) protein expression confers a poor prognosis in sporadic and familial breast cancer patients, and the FOXP1 gene maps to a tumor suppressor locus at chromosome 3p14. Although correlation studies have indicated that FOXP1 has a role in tumor suppression, determination of the regulatory mechanism of FOXP1 is required to establish its function in breast cancer. It has …
  • Implication of CYP24A1 splicing in breast cancer. [Journal Article]
    Anticancer Agents Med Chem. 2014 Jan; 14(1):109-14.Scheible C, Thill M, … Friedrich M
  • The expression of CYP27B1 or vitamin D 1α-hydroxylase (1α-OHase) and CYP24A1 in specific tissues may act as the central part between 25-hydroxyvitamin D [25(OH)D] serum levels and the anticancer effects of1α,25-dihydroxyvitamin D [1α,25(OH)2D3],alternative splicing of these enzymes may affect their biological functions. Here, we describe the expression of CYP24A1 and its splicing variants detecte…
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