- [Thiamazole-induced arthritis]. [Journal Article]Z Rheumatol. 2020 Nov 16 [Online ahead of print]ZR
- We report the case of a 42-year-old male patient with acute onset of asymmetrical polyarthritis of the medium and large joints as well as fever and elevated serological inflammation markers. The symptoms began shortly after initiation of thiamazole treatment for newly diagnosed Graves' disease. Antithyroid arthritis syndrome (AAS) is a rare but serious adverse side effect of antithyroid treatment…
- Publisher Full Text
- The simian crease: Relationship to various genetic disorders. [Review]Clin Anat. 2019 Nov; 32(8):1042-1047.CA
- The creases of the palm have been of interest for clinicians, anthropologists, and palmists for hundreds of years, but the variations in them have only been studied during the past 50 years. The simian crease, aptly named for its resemblance to the palmar creases of nonhuman simian primates, has received recognition clinically and anthropologically owing to its abnormal appearance and confounding…
- Publisher Full Text
- Advances in n-3 polyunsaturated fatty acid nutrition. [Review]Asia Pac J Clin Nutr. 2019; 28(1):1-5.AP
- There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). N-3 PUFA also contribute to human health maintenance through correction of arrhythmias, inhibition of platelet aggregation and prolongation of clotting time, lowering blood pressure, lowering serum triglyceride…
- FREE Publisher Full Text
- Alternative treatments for adults with attention-deficit hyperactivity disorder (ADHD). [Review]
- A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting controlled studies through mere hypotheses to positive controlled double-blind clinical…
- Publisher Full Text
- [Telemedicine in rheumatology]. [Journal Article]Z Rheumatol. 2020 Nov; 79(9):883-892.ZR
- Due to the outbreak of the COVID-19 pandemic, in recent months we have experienced deep changes in our daily and professional lives. In the context of pandemic containment, routine rheumatological procedures have changed in many areas. To guarantee sufficient protection against the infection for patients and staff, telemedicine (especially telephone and video consultation) has increasingly been u…
- Publisher Full TextPMC Free Full TextPMC Free PDF
- #Covid4Rheum: an analytical twitter study in the time of the COVID-19 pandemic. [Journal Article]
- Social media services, such as Twitter, offer great potential for a better understanding of rheumatic and musculoskeletal disorders (RMDs) and improved care in the field of rheumatology. This study examined the content and stakeholders associated with the Twitter hashtag #Covid4Rheum during the COVID-19 pandemic. The content analysis shows that Twitter connects stakeholders of the rheumatology co…
- Publisher Full TextPMC Free Full TextPMC Free PDF
- To kidney or not to kidney: Applying lessons learned from the simultaneous liver-kidney transplant policy to simultaneous heart-kidney transplantation. [Review]Clin Transplant. 2020 06; 34(6):e13878.CT
- As the medical community is increasingly offering transplantation to patients with increasing comorbidity burdens, the number of simultaneous heart-kidney (SHK) transplants is rising in the United States. How to determine eligibility for SHK transplant versus heart transplant alone is unknown. In this review, we situate this problem in the broader picture of organ shortage. We critically appraise…
- Publisher Full Text
- [Auricular chondritis as first symptom of ANCA-associated vasculitis]. [Case Reports]Z Rheumatol. 2020 Nov; 79(9):902-905.ZR
- Auricular chondritis frequently occurs in relapsing polychondritis. In addition to the primary form of the disease up to 30% of cases of chondritis can be secondary, e.g. due to autoimmune diseases. We describe the case of a 62-year-old male patient with auricular chondritis as the first symptom of granulomatosis with polyangiitis. Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis…
- Publisher Full Text
- [Mobile apps and their usage in rheumatology]. [Journal Article]Z Rheumatol. 2020 Aug; 79(6):554-561.ZR
- The increasing use of smartphones is accompanied by a significant increase in the use of mobile applications (apps). Chronically ill patients could permanently profit from this development.This development is fuelled by the Digital Healthcare Act (DVG), whereby patients have a legal claim to certain apps, so-called digital health applications (DiGAs), which are reimbursed by the statutory health …
- Publisher Full Text
- [Muscular polyarteritis nodosa-a case-based review]. [Case Reports]Z Rheumatol. 2019 Mar; 78(2):173-179.ZR
- CONCLUSIONS: With respect to own experiences and the reviewed literature, muscular PAN should be considered as a possible diagnosis in cases of myalgia with elevated inflammatory markers but normal CK levels and a lack of further symptoms typical for vasculitis.
- Publisher Full Text
- Association of Neighborhood Socioeconomic Context With Participation in Cardiac Rehabilitation. [Journal Article]
- CONCLUSIONS: Lower neighborhood socioeconomic context was associated with decreased CR participation independent of individual socioeconomic status. These data invite research on interventions to increase CR access in deprived communities.
- FREE Publisher Full TextPMC Free Full TextPMC Free PDF
- FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells. [Journal Article]
- Loss of Forkhead box P1 (FOXP1) protein expression confers a poor prognosis in sporadic and familial breast cancer patients, and the FOXP1 gene maps to a tumor suppressor locus at chromosome 3p14. Although correlation studies have indicated that FOXP1 has a role in tumor suppression, determination of the regulatory mechanism of FOXP1 is required to establish its function in breast cancer. It has …
- PMC Free Full TextPMC Free PDF
- Mechanisms of estrogen carcinogenesis: The role of E2/E1-quinone metabolites suggests new approaches to preventive intervention--A review. [Review]
- Studies in hamsters, mice and rats have demonstrated that estradiol (E2), its interconvertible metabolite estrone (E1) and their catechol metabolites, in particular 4-hydroxy E2/E1, are carcinogenic in the kidney, uterus and mammary gland. Observational studies and clinical trials consistently show that sustained exposure to E2/E1 is associated with the development of sporadic breast cancer. The …
- Publisher Full TextPMC Free Full TextPMC Free PDF
- The selective cytotoxicity elicited by phytochemical extract from Senecio graveolens (Asteraceae) on breast cancer cells is enhanced by hypoxia. [Journal Article]
- Breast cancer is the second cause of cancer‑related deaths in woman and the incidence of the disease has increased worldwide, in part due to improvements in early detection. Several drugs with anticancer effects have been extracted from plants in the last 20 years, many of which are particularly effective against breast cancer cells. In particular, we have become interested in the ethanolic extra…
- Publisher Full Text
- Implication of CYP24A1 splicing in breast cancer. [Journal Article]
- The expression of CYP27B1 or vitamin D 1α-hydroxylase (1α-OHase) and CYP24A1 in specific tissues may act as the central part between 25-hydroxyvitamin D [25(OH)D] serum levels and the anticancer effects of1α,25-dihydroxyvitamin D [1α,25(OH)2D3],alternative splicing of these enzymes may affect their biological functions. Here, we describe the expression of CYP24A1 and its splicing variants detecte…
- Increased expression of histone proteins during estrogen-mediated cell proliferation. [Journal Article]
- CONCLUSIONS: Our results indicate that ER-mediated cell proliferation results in up-regulation of core histone proteins.
- FREE Publisher Full TextPMC Free Full TextPMC Free PDF
- Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects. [Review]
- Long-term exposure to estrogens influences the development of breast cancer in women, but the precise mechanisms involved are not clearly defined. Our working hypothesis is that estrogen modulates this process by two separate processes. One involves the binding of estradiol to estrogen receptor (ER) alpha with stimulation of cell proliferation. Errors in DNA occurring during replication result in…
- Publisher Full Text
- Nurses protest against decision to end free student education. [News]Nurs Times. 2015 Dec 2-15; 111(49-50):4.NT
- Erdheim-Chester disease with concomitant Rosai-Dorfman like lesions: a distinct entity mainly driven by MAP2K1. [Letter]Haematologica. 2020 01; 105(1):e5-e8.H
- FREE Publisher Full TextPMC Free Full TextPMC Free PDF
- Older studies can underestimate prognosis of glioblastoma biomarker in meta-analyses: a meta-epidemiological study for study-level effect in the current literature. [Review]J Neurooncol. 2018 Sep; 139(2):231-238.JN
- CONCLUSIONS: This meta-epidemiological study demonstrated that study-level year can already significantly affect the pooled HR of GBM biomarkers reported by meta-analyses. It is possible that in the future, more study-level properties will exert significant effect. In terms of future GBM biomarker meta-analyses, special consideration of bias should be given to these study-level properties as potential sources of effect on the prognostic pooled HR.
- Publisher Full Text (DOI)