- NICE issues guidance to improve managing IV fluid care in children. [News]
- NTNurs Times 2015 Dec 16; 111(51-52):5
- Systemic antibiotic therapy for chronic osteomyelitis in adults. [Review]
- CIClin Infect Dis 2012 Feb 01; 54(3):393-407
- The standard recommendation for treating chronic osteomyelitis is 6 weeks of parenteral antibiotic therapy. However, oral antibiotics are available that achieve adequate levels in bone, and there are...
The standard recommendation for treating chronic osteomyelitis is 6 weeks of parenteral antibiotic therapy. However, oral antibiotics are available that achieve adequate levels in bone, and there are now more published studies of oral than parenteral antibiotic therapy for patients with chronic osteomyelitis. Oral and parenteral therapies achieve similar cure rates; however, oral therapy avoids risks associated with intravenous catheters and is generally less expensive, making it a reasonable choice for osteomyelitis caused by susceptible organisms. Addition of adjunctive rifampin to other antibiotics may improve cure rates. The optimal duration of therapy for chronic osteomyelitis remains uncertain. There is no evidence that antibiotic therapy for >4-6 weeks improves outcomes compared with shorter regimens. In view of concerns about encouraging antibiotic resistance to unnecessarily prolonged treatment, defining the optimal route and duration of antibiotic therapy and the role of surgical debridement in treating chronic osteomyelitis are important, unmet needs.
- Evidence-based treatment of chronic rhinosinusitis with nasal polyps. [Journal Article]
- AJAm J Rhinol Allergy 2013 Nov-Dec; 27(6):461-6
- CONCLUSIONS: CRSwNPs is a heterogenous disorder that currently has very few therapies supported by strong evidence. It is likely that in the near future, a more refined understanding of CRSwNPs will permit clinicians to tailor therapies using high-level evidence with improved outcomes.
- Social skills groups for people aged 6 to 21 with autism spectrum disorders (ASD). [Review]
- CDCochrane Database Syst Rev 2012 Jul 11; (7):CD008511
- CONCLUSIONS: There is some evidence that social skills groups can improve social competence for some children and adolescents with ASD. More research is needed to draw more robust conclusions, especially with respect to improvements in quality of life.
- Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis. [Review]
- JIJ Infect 2011; 62(4):255-62
- CONCLUSIONS: CSF lactate's high negative likelihood ratio may make it useful for ruling out bacterial meningitis though pretreatment with antibiotics reduces clinical accuracy. CSF lactate of 35 mg/dl could be optimal cut-off value for distinguishing bacterial meningitis from aseptic meningitis.
- Sleep Apnea and Kidney Function Trajectory: Results From a 20-Year Longitudinal Study of Healthy Middle-Aged Adults. [Journal Article]
- SSleep 2018 Jan 01; 41(1)
- CONCLUSIONS: Among healthy middle-aged adults, the presence of sleep apnea at baseline did not accelerate kidney function decline compared with those without sleep apnea over time.
- Back to Basics: Orthopedic Positioning: 2.2 www.aornjournal.org/content/cme. [Journal Article]
- AJAORN J 2018; 107(3):355-367
- [Reduction of post-surgical pain by Manual Medicine following tonsillectomy in adults]. [Journal Article]
- LLaryngorhinootologie 2017; 96(12):831-835
- Objective Postoperative pain after tonsillectomy (TE) can usually be treated sufficiently by non-steroidal anti-inflammatory drugs (NSAIDs). In some patients, however, postoperative pain is more prom...
Objective Postoperative pain after tonsillectomy (TE) can usually be treated sufficiently by non-steroidal anti-inflammatory drugs (NSAIDs). In some patients, however, postoperative pain is more prominent on one side of the neck. Our clinical experience has demonstrated that these patients often show a segmental hypomobility of the upper cervical joints that can be successfully treated by manual medicine (MM). The analgetic effectiveness of this treatment was investigated in a prospective, randomized, placebocontrolled, single-blind study. Material and Methods 52 adults with exceptionally strong (visual analog scale VAS > 4) and/or unilateral pain after TE (between day 1 and 4) were included in this study. Postoperatively (TE) pain scores were immediately evaluated by VAS before (t0) and after (t1) the treatment (MM) as well as 4 hours (t2) and 1 day later (t3). Results Results show a significantly higher reduction in pain in the verum group compared to the placebo group (t1: p = 0.012, t3: p = 0.012, both Bonferroni-adjusted). The difference to t2 was not significant (p = 0.54 Conclusion This study has demonstrated effective pain reduction by manual medicine in adults with exceptionally strong and/or unilateral pain after TE and cervical hypomobolity.
- Rapid word learning in 13- and 17-month-olds in a naturalistic two-word procedure: looking versus reaching measures. [Journal Article]
- JEJ Exp Child Psychol 2011; 109(2):201-17
- This study investigated infants' rapid learning of two novel words using a preferential looking measure compared with a preferential reaching measure. In Experiment 1, 21 13-month-olds and 20 17-mont...
This study investigated infants' rapid learning of two novel words using a preferential looking measure compared with a preferential reaching measure. In Experiment 1, 21 13-month-olds and 20 17-month-olds were given 12 novel label exposures (6 per trial) for each of two novel objects. Next, in the label comprehension tests, infants were shown both objects and were asked, "Where's the [label]?" (looking preference) and then told, "Put the [label] in the basket" (reaching preference). Only the 13-month-olds showed rapid word learning on the looking measure; neither age group showed rapid word learning on the reaching measure. In Experiment 2, the procedure was repeated 24h later with 10 participants per age group from Experiment 1. After a further 12 labels per object, both age groups now showed robust evidence of rapid word learning, but again only on the looking measure. This is the earliest looking-based evidence of rapid word learning in infants in a well-controlled (i.e., two-word) procedure; our failure to replicate previous reports of rapid word learning in 13-month-olds with a preferential reaching measure may be due to our use of more rigorous controls for object preferences. The superior performance of the younger infants on the looking measure in Experiment 1 was not straightforwardly predicted by existing theoretical accounts of word learning.
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- 6-Minute walk test predicts prolonged hospitalization in patients undergoing transcatheter mitral valve repair by MitraClip. [Journal Article]
- CCCatheter Cardiovasc Interv 2018 Apr 15
- CONCLUSIONS: Our study demonstrates that 6MWT was independently associated with prolonged hospitalization in patients with TMVr, and has a good discriminatory performance for predicting prolonged hospitalization.