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  • Sexually transmitted diseases treatment guidelines, 2015. [Practice Guideline]
  • MRMMWR Recomm Rep 2015 Jun 05; 64(RR-03):1-137
  • Workowski KA, Bolan GA, Centers for Disease Control and Prevention
  • These guidelines for the treatment of persons who have or are at risk for sexually transmitted diseases (STDs) were updated by CDC after consultation with a group of professionals knowledgeable in th...
  • Antidepressants for chronic non-cancer pain in children and adolescents. [Review]
  • CDCochrane Database Syst Rev 2017 08 05; 8:CD012535
  • Cooper TE, Heathcote LC, … Wiffen PJ
  • CONCLUSIONS: We identified only a small number of studies with small numbers of participants and insufficient data for analysis.As we could undertake no meta-analysis, we are unable to comment about efficacy or harm from the use of antidepressants to treat chronic non-cancer pain in children and adolescents. Similarly, we cannot comment on our remaining secondary outcomes: Carer Global Impression of Change; requirement for rescue analgesia; sleep duration and quality; acceptability of treatment; physical functioning; and quality of life.There is evidence from adult randomised controlled trials that some antidepressants, such as amitriptyline, can provide some pain relief in certain chronic non-cancer pain conditions.There is no evidence from randomised controlled trials to support or refute the use of antidepressants to treat chronic non-cancer pain in children or adolescents.
  • Adjunctive Glucocorticoid Therapy in Patients with Septic Shock. [Randomized Controlled Trial]
  • NEJMN Engl J Med 2018 03 01; 378(9):797-808
  • Venkatesh B, Finfer S, … ADRENAL Trial Investigators and the Australian–New Zealand Intensive Care Society Clinical Trials Group
  • CONCLUSIONS: Among patients with septic shock undergoing mechanical ventilation, a continuous infusion of hydrocortisone did not result in lower 90-day mortality than placebo. (Funded by the National Health and Medical Research Council of Australia and others; ADRENAL ClinicalTrials.gov number, NCT01448109 .).
  • Does Atrial Septal Defect Increase the Risk of Stroke Following Total Hip and Knee Arthroplasty? [Journal Article]
  • STSurg Technol Int 2017 Dec 22; 31:177-181
  • Chughtai M, Perfetti DC, … Mont MA
  • CONCLUSIONS: Patients with ASD undergoing THA and TKA are predisposed to stroke in the postoperative period. Orthopaedic surgeons indicating patients for surgery and internists performing preoperative medical clearance should be aware of these risks and discuss them prior to surgery. The efficacy of pharmacological and surgical measures to reduce postoperative stroke within this patient population should be topics of future investigation.
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