- Cardiac Structure and Function in Patients With Obesity and Non-alcoholic Fatty Liver Disease. [Journal Article]Cureus. 2023 Aug; 15(8):e43711.C
- Introduction Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide. The global prevalence of NAFLD is expected to increase dramatically with the increasing prevalence of obesity and type 2 diabetes mellitus (T2DM). The role of NAFLD as a cardiometabolic risk factor or component of metabolic syndrome on the heart remains unclear. Thus, the inde…
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- The Influence of Ketogenic Diet on Gut Microbiota: Potential Benefits, Risks and Indications. [Review]Nutrients. 2023 Aug 22; 15(17)N
- The ketogenic diet (KD) restricts carbohydrate consumption, leading to an increase in ketone bodies, such as acetoacetate, β-hydroxybutyrate, and acetone, which are utilized as energy substrates. This dietary approach impacts several biochemical processes, resulting in improved clinical management of various disorders, particularly in childhood. However, the exact mechanisms underlying the effica…
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- Daratumumab as rescue therapy in life-threatening granulomatosis with polyangiitis. [Journal Article]Rheumatology (Oxford). 2023 Sep 09 [Online ahead of print]R
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- Gluteus maximus tendon transfer as a salvage option for painful chronic hip abductor insufficiency: clinical and MRI results with a minimum follow-up of 24 months. [Journal Article]Hip Int. 2023 Sep 05 [Online ahead of print]HI
- CONCLUSIONS: In the setting of painful chronic hip abductor insufficiency refractory to conservative treatment with advanced muscle degeneration without the possibility of a direct reconstruction the gluteus maximus tendon transfer significantly decreased pain. The effect on hip abductor strength and patient-reported functional outcome scores is limited. Despite the modest results it remains our preferred salvage treatment option for lack of better alternatives. Larger studies are necessary to confirm these findings.
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- Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis. [Journal Article]Intensive Care Med. 2023 Sep 05 [Online ahead of print]IC
- CONCLUSIONS: Biomarker-defined sAKI is a common and severe condition observed in patients within intensive care units with a urinary peptide signature that is similar to that of AKI, along with a comparable prognosis.
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- Childhood nephrotic syndrome. [Review]Lancet. 2023 Sep 02; 402(10404):809-824.Lct
- Idiopathic nephrotic syndrome is the most common glomerular disease in children. Corticosteroids are the cornerstone of its treatment, and steroid response is the main prognostic factor. Most children respond to a cycle of oral steroids, and are defined as having steroid-sensitive nephrotic syndrome. Among the children who do not respond, defined as having steroid-resistant nephrotic syndrome, mo…
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- Rationale and design of the ULYSS trial: A randomized multicenter evaluation of the efficacy of early Impella CP implantation in acute coronary syndrome complicated by cardiogenic shock. [Journal Article]Am Heart J. 2023 Aug 30; 265:203-212.AH
- Despite 20 years of improvement in acute coronary syndromes care, patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) remains a major clinical challenge with a stable incidence and mortality. While intra-aortic balloon pump (IABP) did not meet its expectations, percutaneous mechanical circulatory supports (pMCS) with higher hemodynamic support, large availability an…
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- Psilocybin history, action and reaction: A narrative clinical review. [Review]J Psychopharmacol. 2023 Sep; 37(9):849-865.JP
- Hallucinogenic mushrooms have been used in religious and cultural ceremonies for centuries. Of late, psilocybin, the psychoactive compound in hallucinogenic mushrooms, has received increased public interest as a novel drug for treating mood and substance use disorders (SUDs). In addition, in recent years, some states in the United States have legalized psilocybin for medical and recreational use.…
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- "It Doesn't Cure, but It Protects": COVID-19 Vaccines through the Eyes of Children and Their Parents. [Journal Article]Vaccines (Basel). 2023 Jul 31; 11(8)V
- Recently, studies have examined COVID-19 vaccine acceptance and/or hesitancy amongst adult populations across the globe. However, there is a paucity of literature illustrating children's voices in vaccination debates. This article draws on qualitative data collected via a mixed-methods study that explored South Africans' experiences during the COVID-19 pandemic between 2020 and 2021. Interviews w…
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- How Did We Get Here: The Best Vaccines Ever Facing the Highest Public Hesitancy? [Journal Article]Vaccines (Basel). 2023 Aug 04; 11(8)V
- mRNA vaccine technology is the most interesting final product of decades of research. This new platform for public health is simple to transfer to low-income countries and can be used against diverse agents, including cancer. It is environmentally clean, relatively low-cost, and does not use animals for its production. Most importantly, mRNA vaccines have been highly efficacious in avoiding serio…
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- Discovery of phage determinants that confer sensitivity to bacterial immune systems. [Journal Article]Cell. 2023 Apr 27; 186(9):1863-1876.e16.Cell
- Over the past few years, numerous anti-phage defense systems have been discovered in bacteria. Although the mechanism of defense for some of these systems is understood, a major unanswered question is how these systems sense phage infection. To systematically address this question, we isolated 177 phage mutants that escape 15 different defense systems. In many cases, these escaper phages were mut…
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- Understanding the Current Landscape of Kidney Disease in Canada to Advance Precision Medicine Guided Personalized Care. [Review]
- To understand the impact of kidney disease in Canada and the priority areas of kidney research that can benefit from patient-oriented, precision medicine research using novel technologies.
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- Getting Beyond Pros and Cons: Results of a Stakeholder Needs Assessment on Physician Assisted Dying in the Hospital Setting. [Journal Article]
- This study assessed the attitudes and needs of physicians and health professional staff at a tertiary care hospital in Canada regarding the introduction of physician assisted dying (PAD) during 2015-16. This research aimed to develop an understanding of the wishes, concerns and hopes of stakeholders related to handling requests for PAD; to determine what supports/structures/resources health care …
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- The political determinants of the health of undocumented immigrants: a comparative analysis of mortality patterns in Switzerland. [Journal Article]
- CONCLUSIONS: We interpret these results as an indication that policies that expand access to health services lead to better outcomes for undocumented immigrants. This finding has implications for research on civic stratification and public health. Further analysis is needed to evaluate the effects of extending public health care for undocumented immigrants in different contexts.
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- Improvements in quality of life and work productivity with up to 6 months of fremanezumab treatment in patients with episodic and chronic migraine and documented inadequate response to 2 to 4 classes of migraine-preventive medications in the phase 3b FOCUS study. [Randomized Controlled Trial]
- CONCLUSIONS: Among patients with EM or CM and prior inadequate response to multiple migraine-preventive medication classes, progressive improvements in MSQoL, depression, and work productivity were achieved during 6 months of fremanezumab treatment.
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- StatPearls: Features, Evaluation, and Treatment of Coronavirus (COVID-19) [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Coronavirus disease 2019 (COVID-19), the highly contagious viral illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a catastrophic effect on the world’s demographics resulting in more than 3.8 million deaths worldwide, emerging as the most consequential global health crisis since the era of the influenza pandemic of 1918. After the first cases of this predomin…
- Brain networks predict metabolism, diagnosis and prognosis at the bedside in disorders of consciousness. [Journal Article]
- Recent advances in functional neuroimaging have demonstrated novel potential for informing diagnosis and prognosis in the unresponsive wakeful syndrome and minimally conscious states. However, these technologies come with considerable expense and difficulty, limiting the possibility of wider clinical application in patients. Here, we show that high density electroencephalography, collected from 1…
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- The impact of clinical and genetic factors on ticagrelor and clopidogrel antiplatelet therapy. [Journal Article]
- CONCLUSIONS: Results of the current study showed that CYP4F2 rs3093135 TT variant carriers had a higher antiplatelet effect of ticagrelor, and more frequently had nonprocedural bleeding during ticagrelor therapy, as compared with AA and AT variant carriers.
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- RAS Genetic Variants in Interaction with ACE Inhibitors Drugs Influences Essential Hypertension Control. [Multicenter Study]
- CONCLUSIONS: Although this study shows a possible association of polymorphisms of RAS genes with the risk of non-control of HT in ACEI-treated patients and indicates the importance of all this system's components in regulating HT, it needs to be replicated in other data sources.
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- Nurses blame fall in staff for workplace pressures. [News]Nurs Times. 2015 Dec 16; 111(51-52):2-3.NT