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100 results
  • Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes. [Randomized Controlled Trial]
    N Engl J Med. 2022 09 22; 387(12):1063-1074.GRADE Study Research Group, Nathan DM, … Younes N
  • CONCLUSIONS: All four medications, when added to metformin, decreased glycated hemoglobin levels. However, glargine and liraglutide were significantly, albeit modestly, more effective in achieving and maintaining target glycated hemoglobin levels. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; GRADE ClinicalTrials.gov number, NCT01794143.).
  • Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement. [Journal Article]
    N Engl J Med. 2022 Sep 17 [Online ahead of print]Kapadia SR, Makkar R, … PROTECTED TAVR Investigators
  • CONCLUSIONS: Among patients with aortic stenosis undergoing transfemoral TAVR, the use of CEP did not have a significant effect on the incidence of periprocedural stroke, but on the basis of the 95% confidence interval around this outcome, the results may not rule out a benefit of CEP during TAVR. (Funded by Boston Scientific; PROTECTED TAVR ClinicalTrials.gov number, NCT04149535.).
  • A Bivalent Omicron-Containing Booster Vaccine against Covid-19. [Journal Article]
    N Engl J Med. 2022 Sep 16 [Online ahead of print]Chalkias S, Harper C, … Das R
  • CONCLUSIONS: The bivalent omicron-containing vaccine mRNA-1273.214 elicited neutralizing antibody responses against omicron that were superior to those with mRNA-1273, without evident safety concerns. (Funded by Moderna; ClinicalTrials.gov number, NCT04927065.).
  • Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. [Journal Article]
    Nat Med. 2022 Sep 15 [Online ahead of print]Mackensen A, Müller F, … Schett G
  • Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease characterized by adaptive immune system activation, formation of double-stranded DNA autoantibodies and organ inflammation. Five patients with SLE (four women and one man) with a median (range) age of 22 (6) years, median (range) disease duration of 4 (8) years and active disease (median (range) SLE disease activity index…
  • Deep Venous Thrombosis. [Review]
    Ann Intern Med. 2022 Sep; 175(9):ITC129-ITC144.Duffett L
  • Venous thromboembolism (VTE) is the third most common cardiovascular disorder, affecting up to 5% of the population. VTE commonly manifests as lower-extremity deep venous thrombosis (DVT) or pulmonary embolism. Half of these events are associated with a transient risk factor and may be preventable with prophylaxis. Direct oral anticoagulants are effective and safe and carry a lower risk for bleed…
  • Comparison of physician and artificial intelligence-based symptom checker diagnostic accuracy. [Journal Article]
    Rheumatol Int. 2022 Sep 10 [Online ahead of print]Gräf M, Knitza J, … Callhoff J
  • Symptom checkers are increasingly used to assess new symptoms and navigate the health care system. The aim of this study was to compare the accuracy of an artificial intelligence (AI)-based symptom checker (Ada) and physicians regarding the presence/absence of an inflammatory rheumatic disease (IRD). In this survey study, German-speaking physicians with prior rheumatology working experience were …
  • A comparative study of the chloroplast genomes of five Lepidium species with high medicinal value. [Journal Article]
    Funct Plant Biol. 2022 Aug 31 [Online ahead of print]Zhou Q, Chen Y, … Zhao H
  • Plantgenomics is a rapidly developing field in medicinal plant research. This study analysed the relevant information of chloroplasts genome sequences of five medicinal plants from the genus Lepidium. We sequenced the complete chloroplast (cp) genomes of Lepidium apetalum Willd. and Lepidium perfoliatum Linnaeus., and assessed their genetic profiles against the reported profiles of Lepidium sativ…
  • Different Surgical Reconstructions for Femoral Nerve Injury: A Clinical Study on 9 Cases. [Journal Article]
    Ann Plast Surg. 2020 05; 84(5S Suppl 3):S171-S177.Cao Y, Li Y, … Xu L
  • CONCLUSIONS: Our results indicate that all these 3 procedures are safe and reliable ways to reconstruct femoral nerve function and can be applied to patients with different kinds of injuries. The sural nerve graft should be considered in the first place and the obturator nerve transfer at different level (trunk transfer in the pelvic or mortal branches transfer out of the pelvic) can be performed as the alternative.
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