- Early eGFR decline after SGLT2i initiation: knowns and unknowns. [Comment]
- Sodium-glucose cotransporter-2 inhibitors (SGLT2i) improve kidney and cardiovascular outcomes. SLGT2i initiation is accompanied by an acute decline in glomerular filtration rate. However, the clinical significance of this acute change remains unclear. In this issue of Kidney International, Kraus et al. examined the factors associated with an initial decline in estimated glomerular filtration rate…
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- Surgical Outcomes among Focused versus Diversified Cataract Surgeons. [Journal Article]Ophthalmology. 2021 Feb 23 [Online ahead of print]O
- CONCLUSIONS: Exclusive surgical focus did not affect the safety of cataract surgery when compared with moderate levels of surgical diversification. The risk of cataract surgical adverse events was higher among surgeons whose practice was dedicated mainly to noncataract surgery.
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- Excessive daytime sleepiness in Parkinson's disease: A systematic review and meta-analysis. [Review]Parkinsonism Relat Disord. 2021 Feb 16 [Online ahead of print]PR
- CONCLUSIONS: Our results showed that approximately one-third of patients with PD had EDS, which may be associated with the severity of the disease, depression, and male sex, or a combination of neurodegeneration and medication.
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- Recommendations for shaping the future of low back pain prevention research. [Editorial]Br J Sports Med. 2021 Feb 26 [Online ahead of print]BJ
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- COVID-19 and AKI: Where Do We Stand? [Review]J Am Soc Nephrol. 2021 Feb 26 [Online ahead of print]JA
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- Effect of BMI on the clinical outcome following microsurgical decompression in over-the-top technique: bi-centric study with an analysis of 744 patients. [Journal Article]
- CONCLUSIONS: The data obtained from this large, homogenous cohort demonstrate that the quality of life improved substantially in all patients that were treated microsurgically for spinal stenosis. However, a BMI ≥ 30 may be considered as a negative predictor for a significantly inferior clinical outcome.
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- High flow nasal oxygen therapy to avoid invasive mechanical ventilation in SARS-CoV-2 pneumonia: a retrospective study. [Journal Article]
- CONCLUSIONS: High flow nasal canula oxygen for ARF due to COVID-19 is associated with a lower rate of invasive mechanical ventilation.
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- Three-dimensional analysis of the root canal preparation with Reciproc Blue®, WaveOne Gold® and XP EndoShaper®: a new method in vivo. [Journal Article]
- CONCLUSIONS: With this model, Reciproc-Blue showed higher increase in root canal volume, followed by WaveOne-Gold, while XP-EndoShaper did not significantly increase root canal volume during preparation.
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- The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study. [Journal Article]Psychol Med. 2021 Feb 26 [Online ahead of print]PM
- CONCLUSIONS: MDD is associated with more impaired information processing speed and executive functioning & attention, and overall cognitive impairment. Furthermore, MDD was associated with CSVD in participants without type 2 diabetes, but this association did not explain an impaired cognitive profile.
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- Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update. [Review]
- Ever since its outbreak, Corona Virus Disease 2019(COVID-19) caused by SARS-CoV-2 has affected more than 26 million individuals in more than 200 countries. Although the mortality rate of COVID-19 is low, but several clinical studies showed, patients with diabetes mellitus (DM) or other major complication at high risk of COVID-19 and reported more severe disease and increased fatality. The angiote…
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- COVID-19 Pandemic and the Burden of Acute Kidney Injury: The Known and the Unknown. [Comment]
- The present pandemic of severe acute respiratory syndrome is caused by the coronavirus (2019-nCoV), commonly called COVID-19. Starting from China, it has spread worldwide, causing major morbidity and mortality. It primarily involves the pulmonary system, but other organ systems are not spared. Treatment is still elusive and evolving. The exact pathogenesis of renal damage from COVID-19 virus and …
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- Simultaneous Imaging of Lung Perfusion and Glucose Metabolism in COVID-19 Pneumonia. [Journal Article]Am J Respir Crit Care Med. 2021 Feb 26 [Online ahead of print]AJ
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- Does passive hip stiffness or range of motion correlate with spinal curvature and posture during quiet standing? [Journal Article]Gait Posture. 2021 Feb 16; 85:273-279.GP
- CONCLUSIONS: Significant correlations were few compared with where correlations lacked statistical significance. This study demonstrates that overly simplistic assumptions about spinal posture and hip stiffness cannot be supported. Hip muscle stiffness should only be targeted in treatments where testing has demonstrated a direct need, and not assumed based upon postural assessment alone.
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- Multimodal MRI staging for tracking progression and clinical-imaging correlation in sporadic Creutzfeldt-Jakob disease. [Journal Article]
- Diffusion imaging is very useful for the diagnosis of sporadic Creutzfeldt-Jakob disease, but it has limitations in tracking disease progression as mean diffusivity changes non-linearly across the disease course. We previously showed that mean diffusivity changes across the disease course follow a quasi J-shaped curve, characterized by decreased values in earlier phases and increasing values late…
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- Distinct neural circuits are associated with subclinical neuropsychiatric symptoms in Parkinson's disease. [Journal Article]J Neurol Sci. 2021 Feb 21; 423:117365.JN
- CONCLUSIONS: Patients were scanned in "on-medication" state only and a control group with similar neuropsychiatric symptoms was not included.Abnormal functional connectivity of distinct neural circuits is present even at the subclinical stage of neuropsychiatric symptoms in PD. Neuropsychiatric phenotyping is important and may facilitate early interventions to "reorganize" these circuits and delay/prevent clinical symptom onset.
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- Genetic Implications in High-Risk Pregnancy and Its Outcome: A 2-year Study. [Journal Article]Am J Perinatol. 2021 Feb 26 [Online ahead of print]AJ
- CONCLUSIONS: Parental consanguinity and endogamy were increased among high-risk pregnancies. Public awareness about potential adverse effects of consanguineous marriages and the importance of genetic testing are imperative. A structured multidisciplinary team of specialists in fetal medicine, clinical genetics, and neonatology provides good genetic services. Expansion and financial support of these services are urgently required.· A multidisciplinary team provides good genetic services in high-risk pregnancies.. · Parental consanguinity and endogamy are increased among high-risk pregnancies.. · Increased public awareness about genetic testing importance and financial support are imperative..
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- Viscoelastic Coagulation Monitor as a Novel Device to Assess Coagulation at the Bedside. A Single-Center Experience During the COVID-19 Pandemic. [Journal Article]ASAIO J. 2021 03 01; 67(3):254-262.AJ
- Viscoelastic coagulation monitor (VCM) is a portable device developed to evaluate the viscoelastic properties of whole blood activated by contact with glass. In this study, VCM was employed to analyze the viscoelastic profiles of 36 COVID-19 intensive care patients. Full anticoagulant dose heparin (unfractionated [UFH]; low molecular weight [LMWH]) was administrated to all patients. The associati…
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- Cinnamon effects on blood pressure and metabolic profile: A double-blind, randomized, placebo-controlled trial in patients with stage 1 hypertension. [Journal Article]
- CONCLUSIONS: Cinnamon caused a statistically significant decrease in mean ambulatory SBP but in a clinically moderate way, and lipid profile was significantly improved. Therefore, cinnamon might be considered a complementary treatment in subjects with S1HTN.
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- Multimodal imaging and genetic findings in a case of ARSG-related atypical Usher syndrome. [Journal Article]Ophthalmic Genet. 2021 Feb 25 [Online ahead of print]OG
- CONCLUSIONS: We report a novel ARSG variant in a case of atypical Usher syndrome and describe multimodal imaging findings that further characterize the effect of ARSG in the pathogenesis of atypical Usher syndrome.
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- Characterization of Gene Therapy Associated Uveitis Following Intravitreal Adeno-Associated Virus Injection in Mice. [Journal Article]
- CONCLUSIONS: Intravitreal AAV injection in mice generates clinically evident inflammation that is mild and seems to resolve spontaneously. However, the total number of intraocular CD45+ cells, particularly T cells, remain elevated. Both innate and adaptive immune cells respond to intravitreal AAV regardless of prior immune status, but the adaptive response is delayed in AAV naive eyes.
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