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  • SARS-CoV-2 B.1.617 mutations L452 and E484Q are not synergistic for antibody evasion. [Journal Article]
    J Infect Dis. 2021 Jul 14 [Online ahead of print]Ferreira I, Kemp S, … Gupta RK
  • The SARS-CoV-2 B.1.617 variant emerged in the Indian state of Maharashtra in late 2020. There have been fears that two key mutations seen in the receptor binding domain L452R and E484Q would have additive effects on evasion of neutralising antibodies. We report that spike bearing L452R and E484Q confers modestly reduced sensitivity to BNT162b2 mRNA vaccine-elicited antibodies following either fir…
  • Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria. [Journal Article]
    N Engl J Med. 2021 07 15; 385(3):217-227.Moses DA, Metzger SL, … Chang EF
  • CONCLUSIONS: In a person with anarthria and spastic quadriparesis caused by a brain-stem stroke, words and sentences were decoded directly from cortical activity during attempted speech with the use of deep-learning models and a natural-language model. (Funded by Facebook and others; ClinicalTrials.gov number, NCT03698149.).
  • Glucocorticoid induced adrenal insufficiency. [Review]
    BMJ. 2021 07 12; 374:n1380.Prete A, Bancos I
  • Synthetic glucocorticoids are widely used for their anti-inflammatory and immunosuppressive actions. A possible unwanted effect of glucocorticoid treatment is suppression of the hypothalamic-pituitary-adrenal axis, which can lead to adrenal insufficiency. Factors affecting the risk of glucocorticoid induced adrenal insufficiency (GI-AI) include the duration of glucocorticoid therapy, mode of admi…
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