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  • Early eGFR decline after SGLT2i initiation: knowns and unknowns. [Comment]
    Kidney Int. 2021 03; 99(3):548-550.Gregg LP, Navaneethan SD
  • Sodium-glucose cotransporter-2 inhibitors (SGLT2i) improve kidney and cardiovascular outcomes. SLGT2i initiation is accompanied by an acute decline in glomerular filtration rate. However, the clinical significance of this acute change remains unclear. In this issue of Kidney International, Kraus et al. examined the factors associated with an initial decline in estimated glomerular filtration rate…
  • Surgical Outcomes among Focused versus Diversified Cataract Surgeons. [Journal Article]
    Ophthalmology. 2021 Feb 23 [Online ahead of print]Campbell RJ, El-Defrawy SR, … Ten Hove MW
  • CONCLUSIONS: Exclusive surgical focus did not affect the safety of cataract surgery when compared with moderate levels of surgical diversification. The risk of cataract surgical adverse events was higher among surgeons whose practice was dedicated mainly to noncataract surgery.
  • Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update. [Review]
    High Blood Press Cardiovasc Prev. 2021 Feb 26 [Online ahead of print]Shukla AK, Banerjee M
  • Ever since its outbreak, Corona Virus Disease 2019(COVID-19) caused by SARS-CoV-2 has affected more than 26 million individuals in more than 200 countries. Although the mortality rate of COVID-19 is low, but several clinical studies showed, patients with diabetes mellitus (DM) or other major complication at high risk of COVID-19 and reported more severe disease and increased fatality. The angiote…
  • COVID-19 Pandemic and the Burden of Acute Kidney Injury: The Known and the Unknown. [Comment]
    Perm J. 2020 12; 25:1.Imam TH
  • The present pandemic of severe acute respiratory syndrome is caused by the coronavirus (2019-nCoV), commonly called COVID-19. Starting from China, it has spread worldwide, causing major morbidity and mortality. It primarily involves the pulmonary system, but other organ systems are not spared. Treatment is still elusive and evolving. The exact pathogenesis of renal damage from COVID-19 virus and …
  • Distinct neural circuits are associated with subclinical neuropsychiatric symptoms in Parkinson's disease. [Journal Article]
    J Neurol Sci. 2021 Feb 21; 423:117365.Tinaz S, Kamel S, … Sinha R
  • CONCLUSIONS: Patients were scanned in "on-medication" state only and a control group with similar neuropsychiatric symptoms was not included.Abnormal functional connectivity of distinct neural circuits is present even at the subclinical stage of neuropsychiatric symptoms in PD. Neuropsychiatric phenotyping is important and may facilitate early interventions to "reorganize" these circuits and delay/prevent clinical symptom onset.
  • Genetic Implications in High-Risk Pregnancy and Its Outcome: A 2-year Study. [Journal Article]
    Am J Perinatol. 2021 Feb 26 [Online ahead of print]Afifi HH, Gaber KR, … Tosson AMS
  • CONCLUSIONS: Parental consanguinity and endogamy were increased among high-risk pregnancies. Public awareness about potential adverse effects of consanguineous marriages and the importance of genetic testing are imperative. A structured multidisciplinary team of specialists in fetal medicine, clinical genetics, and neonatology provides good genetic services. Expansion and financial support of these services are urgently required.· A multidisciplinary team provides good genetic services in high-risk pregnancies.. · Parental consanguinity and endogamy are increased among high-risk pregnancies.. · Increased public awareness about genetic testing importance and financial support are imperative..
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