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  • Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study. [Journal Article]
    Lancet. 2020 Jun 11 [Online ahead of print]Stringhini S, Wisniak A, … Guessous I
  • CONCLUSIONS: These results suggest that most of the population of Geneva remained uninfected during this wave of the pandemic, despite the high prevalence of COVID-19 in the region (5000 reported clinical cases over <2·5 months in the population of half a million people). Assuming that the presence of IgG antibodies is associated with immunity, these results highlight that the epidemic is far from coming to an end by means of fewer susceptible people in the population. Further, a significantly lower seroprevalence was observed for children aged 5-9 years and adults older than 65 years, compared with those aged 10-64 years. These results will inform countries considering the easing of restrictions aimed at curbing transmission.
  • Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials. [Journal Article]
    Med Hypotheses. 2020 May 22; 143:109851.Horowitz RI, Freeman PR
  • CONCLUSIONS: A three-part prevention, diagnostic, and treatment plan is proposed for addressing the severe complications of COVID-19. Digital monitoring of symptoms to clinically diagnose early exposure and response to treatment; prevention with ivermectin as well as nutritional therapies that support a healthy immune response; treatment with anti-inflammatory therapies that block NF-κB and activate Nrf2 pathways, as well as novel therapies that address COVID-19 pneumonia and ARDS with DIC including anticoagulation and/or novel respiratory therapies with or without acetazolamide and sildenafil. These three broad-based interventions urgently need to be subjected to randomized, controlled trials.
  • Digital crowdsourcing: unleashing its power in rheumatology. [Review]
    Ann Rheum Dis. 2020 Jun 11 [Online ahead of print]Krusche M, Burmester GR, Knitza J
  • The COVID-19 pandemic forces the whole rheumatic and musculoskeletal diseases community to reassemble established treatment and research standards. Digital crowdsourcing is a key tool in this pandemic to create and distil desperately needed clinical evidence and exchange of knowledge for patients and physicians alike. This viewpoint explains the concept of digital crowdsourcing and discusses exam…
  • Airborne SARS-CoV-2 is Rapidly Inactivated by Simulated Sunlight. [Journal Article]
    J Infect Dis. 2020 Jun 11 [Online ahead of print]Schuit M, Ratnesar-Shumate S, … Dabisch P
  • Aerosols represent a potential route of transmission of COVID-19. This study examined the effect of simulated sunlight, relative humidity, and suspension matrix on the stability of SARS-CoV-2 in aerosols. Both simulated sunlight and matrix significantly affected the decay rate of the virus. Relative humidity alone did not affect the decay rate; however, minor interactions between relative humidit…
  • Pulmonary Capillary Leak Syndrome following COVID-19 Virus Infection. [Letter]
    J Med Virol. 2020 Jun 10 [Online ahead of print]Bahloul M, Ketata W, … Kammoun S
  • Pulmonary capillary leak syndrome secondary to influenza SARS-CoV-2virus infection was not previously reported. We report 2 cases. The diagnosis of non-cardiogenic pulmonary edema due to pulmonary capillary leak syndrome SARS-CoV-2 virus infection was obtained by a medical committee of 6 physicians. The diagnosis of COVID-19 infection is confirmed by reverse transcription polymerase chain reactio…
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