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  • Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis. [Journal Article]
  • NEJMN Engl J Med 2019 May 10
  • Montalban X, Arnold DL, … Evobrutinib Phase 2 Study Group
  • CONCLUSIONS: Patients with relapsing multiple sclerosis who received 75 mg of evobrutinib once daily had significantly fewer enhancing lesions during weeks 12 through 24 than those who received placebo. There was no significant difference with placebo for either the 25-mg once-daily or 75-mg twice-daily dose of evobrutinib, nor in the annualized relapse rate or disability progression at any dose. Longer and larger trials are required to determine the effect and risks of evobrutinib in patients with multiple sclerosis. (Funded by EMD Serono; ClinicalTrials.gov number, NCT02975349.).
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