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  • Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: An Evidence Review for the U.S. Preventive Services Task Force [BOOK]
  • BOOKAgency for Healthcare Research and Quality (US): Rockville, MD
  • Kahwati LC, Weber RP, … Viswanathan M
  • CONCLUSIONS: In unselected, community-dwelling populations without known osteoporosis or vitamin D deficiency, the evidence does not support a finding of fewer fractures with vitamin D supplementation alone or with calcium; the evidence for supplementation with calcium alone is limited. The evidence suggests that supplementation with vitamin D alone does not increase all-cause mortality or cardiovascular events, but the evidence is limited for other harms. The evidence suggests that supplementation with calcium alone does not increase the incidence of kidney stones, but the evidence is limited for other harms. The evidence suggests that vitamin D with calcium does not increase all-cause mortality, cardiovascular events, or cancer incidence, but it is associated with an increase in the incidence of kidney stones.
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