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Controlled trial of 6-month and 8-month regimens in the treatment of pulmonary tuberculosis. First report.
Am Rev Respir Dis 1978; 118(2):219-28AR

Abstract

Four short-course antituberculosis regimens allocated at random were studied; (1) streptomycin, isoniazid, and rifampin given daily for 6 months; (2) these 3 drugs plus pyrazinamide given daily for 2 months, followed by twice-weekly administration of streptomycin, isoniazid, and pyrazinamide; (3) a regimen that differed from regimen 2 only in that ethambutol replaced pyrazinamide, and (4) streptomycin plus isoniazid plus rifampin plus pyrazinamide given 3 times per week for 4 months, followed by streptomycin plus isoniazid plus pyrazinamide administered twice per week. The last 3 regimens were given for 6 or 8 months at random. All except 1 of 680 patients with tubercle bacilli drug-susceptible before treatment had a favorable bacteriologic response during chemotherapy. The relapse rates during the first 6 months after chemotherapy were low, except in the ethambutol series, in which 19 per cent of the patients relapsed after 6 months of treatment, and 8 per cent relapsed after 8 months. A substantial proportion of the patients with strains initially resistant to either isoniazid or streptomycin had a favorable response to their allocated regimen, but the results were not as good for those patients with strains resistant to both drugs. An important finding is that the incidences of immunologic febrile reactions to rifampin and of rifampin-dependent antibodies were very low during the 3-times-weekly regimen.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

100029

Citation

"Controlled Trial of 6-month and 8-month Regimens in the Treatment of Pulmonary Tuberculosis. First Report." The American Review of Respiratory Disease, vol. 118, no. 2, 1978, pp. 219-28.
Controlled trial of 6-month and 8-month regimens in the treatment of pulmonary tuberculosis. First report. Am Rev Respir Dis. 1978;118(2):219-28.
(1978). Controlled trial of 6-month and 8-month regimens in the treatment of pulmonary tuberculosis. First report. The American Review of Respiratory Disease, 118(2), pp. 219-28.
Controlled Trial of 6-month and 8-month Regimens in the Treatment of Pulmonary Tuberculosis. First Report. Am Rev Respir Dis. 1978;118(2):219-28. PubMed PMID: 100029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled trial of 6-month and 8-month regimens in the treatment of pulmonary tuberculosis. First report. PY - 1978/8/1/pubmed PY - 1978/8/1/medline PY - 1978/8/1/entrez SP - 219 EP - 28 JF - The American review of respiratory disease JO - Am. Rev. Respir. Dis. VL - 118 IS - 2 N2 - Four short-course antituberculosis regimens allocated at random were studied; (1) streptomycin, isoniazid, and rifampin given daily for 6 months; (2) these 3 drugs plus pyrazinamide given daily for 2 months, followed by twice-weekly administration of streptomycin, isoniazid, and pyrazinamide; (3) a regimen that differed from regimen 2 only in that ethambutol replaced pyrazinamide, and (4) streptomycin plus isoniazid plus rifampin plus pyrazinamide given 3 times per week for 4 months, followed by streptomycin plus isoniazid plus pyrazinamide administered twice per week. The last 3 regimens were given for 6 or 8 months at random. All except 1 of 680 patients with tubercle bacilli drug-susceptible before treatment had a favorable bacteriologic response during chemotherapy. The relapse rates during the first 6 months after chemotherapy were low, except in the ethambutol series, in which 19 per cent of the patients relapsed after 6 months of treatment, and 8 per cent relapsed after 8 months. A substantial proportion of the patients with strains initially resistant to either isoniazid or streptomycin had a favorable response to their allocated regimen, but the results were not as good for those patients with strains resistant to both drugs. An important finding is that the incidences of immunologic febrile reactions to rifampin and of rifampin-dependent antibodies were very low during the 3-times-weekly regimen. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/100029/Controlled_trial_of_6_month_and_8_month_regimens_in_the_treatment_of_pulmonary_tuberculosis__First_report_ L2 - http://www.atsjournals.org/doi/full/10.1164/arrd.1978.118.2.219?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -