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Prevalence of GB virus-C/hepatitis G virus infection in patients with cryptogenic chronic liver disease and in patients with primary biliary cirrhosis or Wilson's disease.
Am J Gastroenterol. 1999 Feb; 94(2):484-8.AJ

Abstract

OBJECTIVE

To assess the role of hepatitis G virus (HGV) in cryptogenic chronic liver disease (CLD), we investigated the prevalence of HGV RNA among patients with cryptogenic CLD, patients with nonviral CLD (primary biliary cirrhosis [PBC] and Wilson's disease [WD]) and subjects without clinically evident liver disease (controls).

METHODS

Ninety patients with cryptogenic CLD (43 with chronic hepatitis, 20 with cirrhosis, and 27 with hepatocellular carcinoma [HCC]), 143 patients with PBC, 22 patients with WD, and 134 controls were recruited. HGV RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) and antibodies against HGV E2 protein (anti-E2) by an immunoassay test.

RESULTS

HGV RNA was detected in 7.8% of patients with cryptogenic CLD (chronic hepatitis, 9.3%; cirrhosis, 5.0%; HCC, 7.4%), in 2.4% of patients with PBC or WD, and in 2.2% of controls. As a consequence, a positive association of HGV infection with cryptogenic CLD was found (odds ratio, 3.1; 95% confidence interval [CI], 1.0-9.7; p = 0.05). No difference was observed between HGV RNA-positive and -negative patients by age, sex, histology, or liver function tests. Anti-E2 prevalence did not differ between patients with cryptogenic CLD (26.5%), patients with PBC (28.1%), and controls (22.1%). Transfusion history was associated with HGV RNA but not with anti-E2 seropositivity.

CONCLUSIONS

Although an association was found between cryptogenic CLD and HGV infection, the role of the virus seems far from important, the proportion of cryptogenic CLD attributable to it being only 5.2%.

Authors+Show Affiliations

Institute of Virology, University of Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

10022651

Citation

Tagger, A, et al. "Prevalence of GB virus-C/hepatitis G Virus Infection in Patients With Cryptogenic Chronic Liver Disease and in Patients With Primary Biliary Cirrhosis or Wilson's Disease." The American Journal of Gastroenterology, vol. 94, no. 2, 1999, pp. 484-8.
Tagger A, Ribero ML, Larghi A, et al. Prevalence of GB virus-C/hepatitis G virus infection in patients with cryptogenic chronic liver disease and in patients with primary biliary cirrhosis or Wilson's disease. Am J Gastroenterol. 1999;94(2):484-8.
Tagger, A., Ribero, M. L., Larghi, A., Donato, F., Zuin, M., Chiesa, R., Benetti, G., Ramella, G., Borzio, M., & Podda, M. (1999). Prevalence of GB virus-C/hepatitis G virus infection in patients with cryptogenic chronic liver disease and in patients with primary biliary cirrhosis or Wilson's disease. The American Journal of Gastroenterology, 94(2), 484-8.
Tagger A, et al. Prevalence of GB virus-C/hepatitis G Virus Infection in Patients With Cryptogenic Chronic Liver Disease and in Patients With Primary Biliary Cirrhosis or Wilson's Disease. Am J Gastroenterol. 1999;94(2):484-8. PubMed PMID: 10022651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of GB virus-C/hepatitis G virus infection in patients with cryptogenic chronic liver disease and in patients with primary biliary cirrhosis or Wilson's disease. AU - Tagger,A, AU - Ribero,M L, AU - Larghi,A, AU - Donato,F, AU - Zuin,M, AU - Chiesa,R, AU - Benetti,G, AU - Ramella,G, AU - Borzio,M, AU - Podda,M, PY - 1999/2/18/pubmed PY - 1999/2/18/medline PY - 1999/2/18/entrez SP - 484 EP - 8 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 94 IS - 2 N2 - OBJECTIVE: To assess the role of hepatitis G virus (HGV) in cryptogenic chronic liver disease (CLD), we investigated the prevalence of HGV RNA among patients with cryptogenic CLD, patients with nonviral CLD (primary biliary cirrhosis [PBC] and Wilson's disease [WD]) and subjects without clinically evident liver disease (controls). METHODS: Ninety patients with cryptogenic CLD (43 with chronic hepatitis, 20 with cirrhosis, and 27 with hepatocellular carcinoma [HCC]), 143 patients with PBC, 22 patients with WD, and 134 controls were recruited. HGV RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) and antibodies against HGV E2 protein (anti-E2) by an immunoassay test. RESULTS: HGV RNA was detected in 7.8% of patients with cryptogenic CLD (chronic hepatitis, 9.3%; cirrhosis, 5.0%; HCC, 7.4%), in 2.4% of patients with PBC or WD, and in 2.2% of controls. As a consequence, a positive association of HGV infection with cryptogenic CLD was found (odds ratio, 3.1; 95% confidence interval [CI], 1.0-9.7; p = 0.05). No difference was observed between HGV RNA-positive and -negative patients by age, sex, histology, or liver function tests. Anti-E2 prevalence did not differ between patients with cryptogenic CLD (26.5%), patients with PBC (28.1%), and controls (22.1%). Transfusion history was associated with HGV RNA but not with anti-E2 seropositivity. CONCLUSIONS: Although an association was found between cryptogenic CLD and HGV infection, the role of the virus seems far from important, the proportion of cryptogenic CLD attributable to it being only 5.2%. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10022651/Prevalence_of_GB_virus_C/hepatitis_G_virus_infection_in_patients_with_cryptogenic_chronic_liver_disease_and_in_patients_with_primary_biliary_cirrhosis_or_Wilson's_disease_ L2 - https://Insights.ovid.com/pubmed?pmid=10022651 DB - PRIME DP - Unbound Medicine ER -