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Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus.
Arthritis Rheum 1999; 42(2):338-46AR

Abstract

OBJECTIVE

To determine rates of morbidity due to cardiovascular and cerebrovascular diseases among women with systemic lupus erythematosus (SLE).

METHODS

I used the California Hospital Discharge Database, which contains information on all discharges from acute care hospitals in California, to identify women with SLE who had been hospitalized for treatment of either acute myocardial infarction (AMI), congestive heart failure (CHF), or cerebrovascular accident (CVA) from 1991 to 1994. I compared the proportions of hospitalizations for each cause among women with SLE with those in a group of women without SLE, for 3 age strata (18-44 years, 45-64 years, and > or =65 years).

RESULTS

Compared with young women without SLE, young women with SLE were 2.27 times more likely to be hospitalized because of AMI (95% confidence interval [95% CI] 1.08-3.46), 3.80 times more likely to be hospitalized because of CHF (95% CI 2.41-5.19), and 2.05 times more likely to be hospitalized because of CVA (95% CI 1.17-2.93). Among middle-aged women with SLE, the frequencies of hospitalization for AMI and CVA did not differ from those of the comparison group, but the risk of hospitalization for CHF was higher (odds ratio [OR] 1.39, 95% CI 1.05-1.73). Among elderly women with SLE, the risk of hospitalization for AMI was significantly lower (OR 0.70, 95% CI 0.51-0.89), the risk of hospitalization for CHF was higher (OR 1.25, 95% CI 1.01-1.49), and the risk of hospitalization for CVA was not significantly different from those in the comparison group.

CONCLUSION

Young women with SLE are at substantially increased risk of AMI, CHF, and CVA. The relative odds of these conditions decrease with age among women with SLE.

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    Authors+Show Affiliations

    Ward MM
    Veterans Affairs Palo Alto Health Care System, California 94305, USA.

    MeSH

    AdolescentAdultAgedCaliforniaCerebrovascular DisordersFemaleHeart FailureHospitalizationHumansLupus Erythematosus, SystemicMiddle AgedMorbidityMyocardial InfarctionOdds RatioPrevalenceRegistries

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10025929

    Citation

    Ward, M M.. "Premature Morbidity From Cardiovascular and Cerebrovascular Diseases in Women With Systemic Lupus Erythematosus." Arthritis and Rheumatism, vol. 42, no. 2, 1999, pp. 338-46.
    Ward MM. Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus. Arthritis Rheum. 1999;42(2):338-46.
    Ward, M. M. (1999). Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus. Arthritis and Rheumatism, 42(2), pp. 338-46.
    Ward MM. Premature Morbidity From Cardiovascular and Cerebrovascular Diseases in Women With Systemic Lupus Erythematosus. Arthritis Rheum. 1999;42(2):338-46. PubMed PMID: 10025929.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus. A1 - Ward,M M, PY - 1999/2/20/pubmed PY - 1999/2/20/medline PY - 1999/2/20/entrez SP - 338 EP - 46 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 42 IS - 2 N2 - OBJECTIVE: To determine rates of morbidity due to cardiovascular and cerebrovascular diseases among women with systemic lupus erythematosus (SLE). METHODS: I used the California Hospital Discharge Database, which contains information on all discharges from acute care hospitals in California, to identify women with SLE who had been hospitalized for treatment of either acute myocardial infarction (AMI), congestive heart failure (CHF), or cerebrovascular accident (CVA) from 1991 to 1994. I compared the proportions of hospitalizations for each cause among women with SLE with those in a group of women without SLE, for 3 age strata (18-44 years, 45-64 years, and > or =65 years). RESULTS: Compared with young women without SLE, young women with SLE were 2.27 times more likely to be hospitalized because of AMI (95% confidence interval [95% CI] 1.08-3.46), 3.80 times more likely to be hospitalized because of CHF (95% CI 2.41-5.19), and 2.05 times more likely to be hospitalized because of CVA (95% CI 1.17-2.93). Among middle-aged women with SLE, the frequencies of hospitalization for AMI and CVA did not differ from those of the comparison group, but the risk of hospitalization for CHF was higher (odds ratio [OR] 1.39, 95% CI 1.05-1.73). Among elderly women with SLE, the risk of hospitalization for AMI was significantly lower (OR 0.70, 95% CI 0.51-0.89), the risk of hospitalization for CHF was higher (OR 1.25, 95% CI 1.01-1.49), and the risk of hospitalization for CVA was not significantly different from those in the comparison group. CONCLUSION: Young women with SLE are at substantially increased risk of AMI, CHF, and CVA. The relative odds of these conditions decrease with age among women with SLE. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/10025929/Premature_morbidity_from_cardiovascular_and_cerebrovascular_diseases_in_women_with_systemic_lupus_erythematosus_ L2 - https://doi.org/10.1002/1529-0131(199902)42:2<338::AID-ANR17>3.0.CO;2-U DB - PRIME DP - Unbound Medicine ER -