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Progression of Alzheimer-related neuritic plaque pathology in the entorhinal region, perirhinal cortex and hippocampal formation.
Dement Geriatr Cogn Disord 1999 Mar-Apr; 10(2):70-6DG

Abstract

Extracellular deposits of the beta-amyloid protein and intraneuronal neurofibrillary changes are hallmarks of Alzheimer's disease. Neurofibrillary changes in the cell body of neurons are the neurofibrillary tangles, while beta-amyloid deposits containing dystrophic neurites with neurofibrillary changes are called neuritic plaques. beta-Amyloid deposits and neurofibrillary tangles display a sequential accumulation in the cerebral cortex. In the present study, the topographical distribution of beta-amyloid deposits and neuritic plaques in the entorhinal region, perirhinal cortex and hippocampal formation was investigated in relationship to the amyloid and neurofibrillary staging proposed by Braak. The number of subregions displaying beta-amyloid deposits and neuritic plaques continuously increases in correlation with the amyloid stage (for beta-amyloid deposits r = 0.90, p < 0.0001, for neuritic plaques r = 0.74, p < 0.0001) and neurofibrillary stage (for beta-amyloid deposits r = 0.53, p < 0.0001, for neuritic plaques r = 0.68, p < 0. 0001). Parallel to the advancement in the neurofibrillary stage, early and late predilection sites of beta-amyloid deposits and neuritic plaques can be distinguished. The early predilection sites correspond to projection areas of regions which exhibit incipient neurofibrillary tangles. Furthermore, neuritic plaques only occur in the presence of neurofibrillary tangles in the areas investigated. The findings indicate that neuritic plaques gradually develop in the projection areas of tangle-bearing neurons.

Authors+Show Affiliations

Institut für Anatomie, Otto-von-Guericke-Universität Magdeburg, Medizinische Hochschule Hannover, Deutschland. deniz.yilmazer-hanke@medizin.uni-magdeburg.deNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10026378

Citation

Yilmazer-Hanke, D M., and J Hanke. "Progression of Alzheimer-related Neuritic Plaque Pathology in the Entorhinal Region, Perirhinal Cortex and Hippocampal Formation." Dementia and Geriatric Cognitive Disorders, vol. 10, no. 2, 1999, pp. 70-6.
Yilmazer-Hanke DM, Hanke J. Progression of Alzheimer-related neuritic plaque pathology in the entorhinal region, perirhinal cortex and hippocampal formation. Dement Geriatr Cogn Disord. 1999;10(2):70-6.
Yilmazer-Hanke, D. M., & Hanke, J. (1999). Progression of Alzheimer-related neuritic plaque pathology in the entorhinal region, perirhinal cortex and hippocampal formation. Dementia and Geriatric Cognitive Disorders, 10(2), pp. 70-6.
Yilmazer-Hanke DM, Hanke J. Progression of Alzheimer-related Neuritic Plaque Pathology in the Entorhinal Region, Perirhinal Cortex and Hippocampal Formation. Dement Geriatr Cogn Disord. 1999;10(2):70-6. PubMed PMID: 10026378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progression of Alzheimer-related neuritic plaque pathology in the entorhinal region, perirhinal cortex and hippocampal formation. AU - Yilmazer-Hanke,D M, AU - Hanke,J, PY - 1999/2/23/pubmed PY - 2000/8/16/medline PY - 1999/2/23/entrez SP - 70 EP - 6 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 10 IS - 2 N2 - Extracellular deposits of the beta-amyloid protein and intraneuronal neurofibrillary changes are hallmarks of Alzheimer's disease. Neurofibrillary changes in the cell body of neurons are the neurofibrillary tangles, while beta-amyloid deposits containing dystrophic neurites with neurofibrillary changes are called neuritic plaques. beta-Amyloid deposits and neurofibrillary tangles display a sequential accumulation in the cerebral cortex. In the present study, the topographical distribution of beta-amyloid deposits and neuritic plaques in the entorhinal region, perirhinal cortex and hippocampal formation was investigated in relationship to the amyloid and neurofibrillary staging proposed by Braak. The number of subregions displaying beta-amyloid deposits and neuritic plaques continuously increases in correlation with the amyloid stage (for beta-amyloid deposits r = 0.90, p < 0.0001, for neuritic plaques r = 0.74, p < 0.0001) and neurofibrillary stage (for beta-amyloid deposits r = 0.53, p < 0.0001, for neuritic plaques r = 0.68, p < 0. 0001). Parallel to the advancement in the neurofibrillary stage, early and late predilection sites of beta-amyloid deposits and neuritic plaques can be distinguished. The early predilection sites correspond to projection areas of regions which exhibit incipient neurofibrillary tangles. Furthermore, neuritic plaques only occur in the presence of neurofibrillary tangles in the areas investigated. The findings indicate that neuritic plaques gradually develop in the projection areas of tangle-bearing neurons. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/10026378/Progression_of_Alzheimer_related_neuritic_plaque_pathology_in_the_entorhinal_region_perirhinal_cortex_and_hippocampal_formation_ L2 - https://www.karger.com?DOI=10.1159/000017104 DB - PRIME DP - Unbound Medicine ER -