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Antipunishment activity of diazepam in rats trained to discriminate diazepam from vehicle.
Exp Clin Psychopharmacol. 1999 Feb; 7(1):13-9.EC

Abstract

The anxiolytic and discriminative stimulus effects of drugs in the same rats during a single session were examined in this study. Rats were trained to discriminate diazepam (5 mg/kg) from vehicle in a 2-lever drug discrimination procedure and were then trained to press a 3rd lever under a multiple fixed-interval (60 sec), fixed-ratio 5 + shock schedule of food reward. Diazepam produced substitution for itself in all rats; however, it produced antipunishment effects in some of the rats, suggesting that its discriminative stimulus and antipunishment effects are separable. In contrast, the N-methyl-D-aspartate antagonists, NPC 17742 and phencyclidine, failed to substitute fully for diazepam and did not increase punished responding in any of the rats. These results are consistent with those of studies showing that drugs from this class produce weaker antipunishment effects than diazepam does. The potential utility of this new method is that it allows direct comparisons of the antipunishment and discriminative stimulus effects of putative anxiolytic drugs during a single session with the same animals.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613, USA. jwiley@hsc.vcu.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10036605

Citation

Wiley, J L., and R L. Balster. "Antipunishment Activity of Diazepam in Rats Trained to Discriminate Diazepam From Vehicle." Experimental and Clinical Psychopharmacology, vol. 7, no. 1, 1999, pp. 13-9.
Wiley JL, Balster RL. Antipunishment activity of diazepam in rats trained to discriminate diazepam from vehicle. Exp Clin Psychopharmacol. 1999;7(1):13-9.
Wiley, J. L., & Balster, R. L. (1999). Antipunishment activity of diazepam in rats trained to discriminate diazepam from vehicle. Experimental and Clinical Psychopharmacology, 7(1), 13-9.
Wiley JL, Balster RL. Antipunishment Activity of Diazepam in Rats Trained to Discriminate Diazepam From Vehicle. Exp Clin Psychopharmacol. 1999;7(1):13-9. PubMed PMID: 10036605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antipunishment activity of diazepam in rats trained to discriminate diazepam from vehicle. AU - Wiley,J L, AU - Balster,R L, PY - 1999/2/26/pubmed PY - 2000/3/18/medline PY - 1999/2/26/entrez SP - 13 EP - 9 JF - Experimental and clinical psychopharmacology JO - Exp Clin Psychopharmacol VL - 7 IS - 1 N2 - The anxiolytic and discriminative stimulus effects of drugs in the same rats during a single session were examined in this study. Rats were trained to discriminate diazepam (5 mg/kg) from vehicle in a 2-lever drug discrimination procedure and were then trained to press a 3rd lever under a multiple fixed-interval (60 sec), fixed-ratio 5 + shock schedule of food reward. Diazepam produced substitution for itself in all rats; however, it produced antipunishment effects in some of the rats, suggesting that its discriminative stimulus and antipunishment effects are separable. In contrast, the N-methyl-D-aspartate antagonists, NPC 17742 and phencyclidine, failed to substitute fully for diazepam and did not increase punished responding in any of the rats. These results are consistent with those of studies showing that drugs from this class produce weaker antipunishment effects than diazepam does. The potential utility of this new method is that it allows direct comparisons of the antipunishment and discriminative stimulus effects of putative anxiolytic drugs during a single session with the same animals. SN - 1064-1297 UR - https://www.unboundmedicine.com/medline/citation/10036605/Antipunishment_activity_of_diazepam_in_rats_trained_to_discriminate_diazepam_from_vehicle_ L2 - http://content.apa.org/journals/pha/7/1/13 DB - PRIME DP - Unbound Medicine ER -