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Repair of articular cartilage defects: part I. Basic Science of cartilage healing.
Am J Orthop (Belle Mead NJ). 1999 Jan; 28(1):31-3.AJ

Abstract

Articular cartilage injuries result in numerous clinical symptoms, such as pain and decreased functional levels. The limited reparative capabilities of hyaline cartilage results in the generation of repair tissue that lacks the structure and biomechanical properties of normal cartilage. Chondrocytes are unable to adequately proliferate, migrate, and synthesize high-quality repair tissue in response to blunt, superficial, or deep penetrating trauma. Extensive research has been conducted to understand the healing process and devise techniques that would enhance this response. Part I of this paper will discuss the basic science of cartilage repair. Part II, which will be published in the February issue, will present the treatment options.

Authors+Show Affiliations

Chen FS
Department of Orthopaedic Surgery, Hospital for Joint Diseases Orthopaedic Institute, New York, New York, USA.
Frenkel SR
No affiliation info available
Di Cesare PE
No affiliation info available

MeSH

AnimalsCartilage, ArticularChondrocytesHumansInjury Severity ScorePrognosisWound HealingWounds, NonpenetratingWounds, Penetrating

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10048355

Citation

Chen, F S., et al. "Repair of Articular Cartilage Defects: Part I. Basic Science of Cartilage Healing." American Journal of Orthopedics (Belle Mead, N.J.), vol. 28, no. 1, 1999, pp. 31-3.
Chen FS, Frenkel SR, Di Cesare PE. Repair of articular cartilage defects: part I. Basic Science of cartilage healing. Am J Orthop (Belle Mead NJ). 1999;28(1):31-3.
Chen, F. S., Frenkel, S. R., & Di Cesare, P. E. (1999). Repair of articular cartilage defects: part I. Basic Science of cartilage healing. American Journal of Orthopedics (Belle Mead, N.J.), 28(1), 31-3.
Chen FS, Frenkel SR, Di Cesare PE. Repair of Articular Cartilage Defects: Part I. Basic Science of Cartilage Healing. Am J Orthop (Belle Mead NJ). 1999;28(1):31-3. PubMed PMID: 10048355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repair of articular cartilage defects: part I. Basic Science of cartilage healing. AU - Chen,F S, AU - Frenkel,S R, AU - Di Cesare,P E, PY - 1999/2/27/pubmed PY - 1999/2/27/medline PY - 1999/2/27/entrez SP - 31 EP - 3 JF - American journal of orthopedics (Belle Mead, N.J.) JO - Am J Orthop (Belle Mead NJ) VL - 28 IS - 1 N2 - Articular cartilage injuries result in numerous clinical symptoms, such as pain and decreased functional levels. The limited reparative capabilities of hyaline cartilage results in the generation of repair tissue that lacks the structure and biomechanical properties of normal cartilage. Chondrocytes are unable to adequately proliferate, migrate, and synthesize high-quality repair tissue in response to blunt, superficial, or deep penetrating trauma. Extensive research has been conducted to understand the healing process and devise techniques that would enhance this response. Part I of this paper will discuss the basic science of cartilage repair. Part II, which will be published in the February issue, will present the treatment options. SN - 1078-4519 UR - https://www.unboundmedicine.com/medline/citation/10048355/Repair_of_articular_cartilage_defects:_part_I__Basic_Science_of_cartilage_healing_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:10048355 DB - PRIME DP - Unbound Medicine ER -